SNP Detail Info-rs907978

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A==0497 (14897/29918,GnomAD)
A==0477 (13907/29118,TOPMED)
A==0496 (2485/5008,1000G)
G=0490 (1887/3854,ALSPAC)
A==0500 (1853/3708,TWINSUK)

Position: chr4:35487287 (GRCh38.p7) (4p15.1)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 6 Enhancers around

Promoter: 18 Promoters around

Sequence Name	Change(s)
GRCh38.p7 chr 4	NC_000004.12:g.35487287A>G
GRCh37.p13 chr 4	NC_000004.11:g.35488909A>G

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.441	G=0.559
1000Genomes	American	Sub	694	A=0.460	G=0.540
1000Genomes	East Asian	Sub	1008	A=0.643	G=0.357
1000Genomes	Europe	Sub	1006	A=0.537	G=0.463
1000Genomes	Global	Study-wide	5008	A=0.496	G=0.504
1000Genomes	South Asian	Sub	978	A=0.410	G=0.590
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.510	G=0.490
The Genome Aggregation Database	African	Sub	8700	A=0.449	G=0.551
The Genome Aggregation Database	American	Sub	836	A=0.430	G=0.570
The Genome Aggregation Database	East Asian	Sub	1614	A=0.674	G=0.326
The Genome Aggregation Database	Europe	Sub	18466	A=0.507	G=0.492
The Genome Aggregation Database	Global	Study-wide	29918	A=0.497	G=0.502
The Genome Aggregation Database	Other	Sub	302	A=0.580	G=0.420
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.477	G=0.522
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.500	G=0.500

PMID	Title	Author	Journal
17158188	Novel genes identified in a high-density genome wide association study for nicotine dependence.	Bierut LJ	Hum Mol Genet

SNP ID	p-value	Traits	Study
rs907978	0.000635	nicotine dependence	17158188

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr4	35465298	35465454	E069	-23455
chr4	35465298	35465454	E071	-23455
chr4	35465298	35465454	E074	-23455
chr4	35526737	35526787	E074	37828
chr4	35536701	35536912	E082	47792
chr4	35536998	35537160	E082	48089

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr4	35466830	35466880	E067	-22029
chr4	35526872	35526986	E068	37963
chr4	35527034	35527236	E068	38125
chr4	35527533	35527608	E068	38624
chr4	35466830	35466880	E069	-22029
chr4	35526872	35526986	E069	37963
chr4	35527034	35527236	E069	38125
chr4	35466830	35466880	E071	-22029
chr4	35526872	35526986	E071	37963
chr4	35527034	35527236	E071	38125
chr4	35527533	35527608	E071	38624
chr4	35466830	35466880	E072	-22029
chr4	35526872	35526986	E072	37963
chr4	35527034	35527236	E072	38125
chr4	35526872	35526986	E073	37963
chr4	35527034	35527236	E073	38125
chr4	35526872	35526986	E074	37963
chr4	35527034	35527236	E074	38125

rs907978