rs917174

Homo sapiens
A>G
LOC105375146 : Non Coding Transcript Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0158 (4747/29966,GnomAD)
A==0161 (4711/29118,TOPMED)
A==0198 (993/5008,1000G)
A==0116 (447/3854,ALSPAC)
A==0108 (399/3708,TWINSUK)
chr7:9961159 (GRCh38.p7) (7p21.3)
AD
GWASdb2
1   publication(s)
See rs on genome
23 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.9961159A>G
GRCh37.p13 chr 7NC_000007.13:g.10000786A>G

Gene: LOC105375146, uncharacterized LOC105375146(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105375146 transcript variant X1XR_927022.2:n.388A>GA>GNon Coding Transcript Variant
LOC105375146 transcript variant X2XR_927023.2:n.388A>GA>GNon Coding Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.219G=0.781
1000GenomesAmericanSub694A=0.200G=0.800
1000GenomesEast AsianSub1008A=0.174G=0.826
1000GenomesEuropeSub1006A=0.131G=0.869
1000GenomesGlobalStudy-wide5008A=0.198G=0.802
1000GenomesSouth AsianSub978A=0.260G=0.740
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.116G=0.884
The Genome Aggregation DatabaseAfricanSub8728A=0.205G=0.795
The Genome Aggregation DatabaseAmericanSub838A=0.180G=0.820
The Genome Aggregation DatabaseEast AsianSub1610A=0.136G=0.864
The Genome Aggregation DatabaseEuropeSub18488A=0.137G=0.862
The Genome Aggregation DatabaseGlobalStudy-wide29966A=0.158G=0.841
The Genome Aggregation DatabaseOtherSub302A=0.150G=0.850
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.161G=0.838
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.108G=0.892
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs9171740.000923alcohol dependence20201924

eQTL of rs917174 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs917174 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr799773779977432E068-23354
chr799773779977432E069-23354
chr799839529984007E069-16779
chr799848059985126E069-15660
chr799851649985224E069-15562
chr799854569985516E069-15270
chr799855939985822E069-14964
chr799833929983487E071-17299
chr799839529984007E071-16779
chr799848059985126E071-15660
chr799851649985224E071-15562
chr799854569985516E071-15270
chr799855939985822E071-14964
chr799772579977337E072-23449
chr799773779977432E072-23354
chr799776559978369E072-22417
chr799788829979086E072-21700
chr799773779977432E074-23354
chr799788829979086E074-21700
chr799848059985126E074-15660
chr799851649985224E074-15562
chr799854569985516E074-15270
chr799855939985822E074-14964