rs9294269

Homo sapiens
A>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0472 (14129/29918,GnomAD)
C=0394 (11476/29118,TOPMED)
C=0434 (2172/5008,1000G)
A==0451 (1737/3854,ALSPAC)
A==0455 (1687/3708,TWINSUK)
chr6:63627392 (GRCh38.p7) (6q12)
AD
GWASdb2
1   publication(s)
See rs on genome
162 Enhancers around
50 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.63627392A>C
GRCh37.p13 chr 6NC_000006.11:g.64337297A>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.801C=0.199
1000GenomesAmericanSub694A=0.580C=0.420
1000GenomesEast AsianSub1008A=0.450C=0.550
1000GenomesEuropeSub1006A=0.416C=0.584
1000GenomesGlobalStudy-wide5008A=0.566C=0.434
1000GenomesSouth AsianSub978A=0.510C=0.490
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.451C=0.549
The Genome Aggregation DatabaseAfricanSub8706A=0.769C=0.231
The Genome Aggregation DatabaseAmericanSub838A=0.590C=0.410
The Genome Aggregation DatabaseEast AsianSub1608A=0.453C=0.547
The Genome Aggregation DatabaseEuropeSub18464A=0.420C=0.579
The Genome Aggregation DatabaseGlobalStudy-wide29918A=0.527C=0.472
The Genome Aggregation DatabaseOtherSub302A=0.380C=0.620
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.605C=0.394
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.455C=0.545
PMID Title Author Journal
22096494A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study.Zuo LPLoS One

P-Value

SNP ID p-value Traits Study
rs92942693.7E-06alcohol dependence22096494

eQTL of rs9294269 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr6:64337297LGSNENSG00000146166.12A>C1.9599e-12307415Brain_Spinal_cord_cervical

meQTL of rs9294269 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr66430761064307749E067-29548
chr66435003264350267E06712735
chr66435031064350429E06713013
chr66435152264351562E06714225
chr66435166464351729E06714367
chr66435326564353367E06715968
chr66435340364353453E06716106
chr66435355064353597E06716253
chr66435379964354122E06716502
chr66435416464354298E06716867
chr66435476664354995E06717469
chr66435648464356589E06719187
chr66435939164359514E06722094
chr66435987964359966E06722582
chr66436979364369833E06732496
chr66436995664370043E06732659
chr66437046564370839E06733168
chr66437340864373737E06736111
chr66438461664384840E06747319
chr66438674564387006E06749448
chr66438706764387235E06749770
chr66434815264348219E06810855
chr66434830464348374E06811007
chr66434916664349250E06811869
chr66435003264350267E06812735
chr66435031064350429E06813013
chr66435340364353453E06816106
chr66435355064353597E06816253
chr66435379964354122E06816502
chr66435416464354298E06816867
chr66435476664354995E06817469
chr66435500564355161E06817708
chr66435939164359514E06822094
chr66435987964359966E06822582
chr66436003464360162E06822737
chr66436979364369833E06832496
chr66436995664370043E06832659
chr66437046564370839E06833168
chr66437319564373307E06835898
chr66437407864374118E06836781
chr66438549764385541E06848200
chr66438646464386529E06849167
chr66438674564387006E06849448
chr66438706764387235E06849770
chr66429983164300142E069-37155
chr66434815264348219E06910855
chr66434830464348374E06911007
chr66435003264350267E06912735
chr66435031064350429E06913013
chr66435326564353367E06915968
chr66435340364353453E06916106
chr66435355064353597E06916253
chr66435379964354122E06916502
chr66435416464354298E06916867
chr66435476664354995E06917469
chr66435500564355161E06917708
chr66435939164359514E06922094
chr66435987964359966E06922582
chr66436598564366056E06928688
chr66436979364369833E06932496
chr66436995664370043E06932659
chr66437046564370839E06933168
chr66437383464373908E06936537
chr66438461664384840E06947319
chr66438508664385323E06947789
chr66438534064385412E06948043
chr66438549764385541E06948200
chr66438646464386529E06949167
chr66438674564387006E06949448
chr66438706764387235E06949770
chr66434815264348219E07010855
chr66429564964295699E071-41598
chr66430761064307749E071-29548
chr66434815264348219E07110855
chr66434830464348374E07111007
chr66434916664349250E07111869
chr66435003264350267E07112735
chr66435031064350429E07113013
chr66435326564353367E07115968
chr66435340364353453E07116106
chr66435355064353597E07116253
chr66435379964354122E07116502
chr66435416464354298E07116867
chr66435476664354995E07117469
chr66435500564355161E07117708
chr66435939164359514E07122094
chr66435987964359966E07122582
chr66436003464360162E07122737
chr66436979364369833E07132496
chr66436995664370043E07132659
chr66437046564370839E07133168
chr66437319564373307E07135898
chr66437340864373737E07136111
chr66437383464373908E07136537
chr66437407864374118E07136781
chr66438461664384840E07147319
chr66438508664385323E07147789
chr66438534064385412E07148043
chr66438549764385541E07148200
chr66438646464386529E07149167
chr66438674564387006E07149448
chr66438706764387235E07149770
chr66435003264350267E07212735
chr66435031064350429E07213013
chr66435152264351562E07214225
chr66435166464351729E07214367
chr66435326564353367E07215968
chr66435340364353453E07216106
chr66435355064353597E07216253
chr66435379964354122E07216502
chr66435416464354298E07216867
chr66435476664354995E07217469
chr66435500564355161E07217708
chr66435939164359514E07222094
chr66435987964359966E07222582
chr66436794864368043E07230651
chr66436812864368168E07230831
chr66437046564370839E07233168
chr66438646464386529E07249167
chr66438674564387006E07249448
chr66438706764387235E07249770
chr66435003264350267E07312735
chr66435031064350429E07313013
chr66435416464354298E07316867
chr66435476664354995E07317469
chr66435939164359514E07322094
chr66434453564344923E0747238
chr66434916664349250E07411869
chr66435003264350267E07412735
chr66435031064350429E07413013
chr66435152264351562E07414225
chr66435166464351729E07414367
chr66435326564353367E07415968
chr66435340364353453E07416106
chr66435355064353597E07416253
chr66435379964354122E07416502
chr66435416464354298E07416867
chr66435476664354995E07417469
chr66435500564355161E07417708
chr66435939164359514E07422094
chr66435987964359966E07422582
chr66436003464360162E07422737
chr66436979364369833E07432496
chr66436995664370043E07432659
chr66437046564370839E07433168
chr66438375864383814E07446461
chr66438461664384840E07447319
chr66438508664385323E07447789
chr66438534064385412E07448043
chr66438549764385541E07448200
chr66438646464386529E07449167
chr66438674564387006E07449448
chr66438706764387235E07449770
chr66434916664349250E08111869
chr66435003264350267E08112735
chr66435031064350429E08113013
chr66438706764387235E08149770
chr66434815264348219E08210855
chr66434830464348374E08211007
chr66434916664349250E08211869
chr66435379964354122E08216502
chr66435416464354298E08216867










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr66430775764309034E067-28263
chr66434507264347052E0677775
chr66434707764347265E0679780
chr66434730764347377E06710010
chr66434738864347481E06710091
chr66430775764309034E068-28263
chr66434507264347052E0687775
chr66434707764347265E0689780
chr66434730764347377E06810010
chr66434738864347481E06810091
chr66430775764309034E069-28263
chr66434507264347052E0697775
chr66434707764347265E0699780
chr66434730764347377E06910010
chr66434738864347481E06910091
chr66430775764309034E070-28263
chr66434507264347052E0707775
chr66434707764347265E0709780
chr66434730764347377E07010010
chr66434738864347481E07010091
chr66430775764309034E071-28263
chr66434507264347052E0717775
chr66434707764347265E0719780
chr66434730764347377E07110010
chr66434738864347481E07110091
chr66430775764309034E072-28263
chr66434507264347052E0727775
chr66434707764347265E0729780
chr66434730764347377E07210010
chr66434738864347481E07210091
chr66430775764309034E073-28263
chr66434507264347052E0737775
chr66434707764347265E0739780
chr66434730764347377E07310010
chr66434738864347481E07310091
chr66430775764309034E074-28263
chr66434507264347052E0747775
chr66434707764347265E0749780
chr66434730764347377E07410010
chr66434738864347481E07410091
chr66430775764309034E081-28263
chr66434507264347052E0817775
chr66434707764347265E0819780
chr66434730764347377E08110010
chr66434738864347481E08110091
chr66430775764309034E082-28263
chr66434507264347052E0827775
chr66434707764347265E0829780
chr66434730764347377E08210010
chr66434738864347481E08210091