rs9295134

Homo sapiens
C>T
MAP3K4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0223 (6678/29950,GnomAD)
T=0271 (7914/29118,TOPMED)
T=0281 (1409/5008,1000G)
T=0121 (465/3854,ALSPAC)
T=0119 (443/3708,TWINSUK)
chr6:161029496 (GRCh38.p7) (6q26)
AD
GWASdb2
1   publication(s)
See rs on genome
79 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.161029496C>T
GRCh37.p13 chr 6NC_000006.11:g.161450528C>T

Gene: MAP3K4, mitogen-activated protein kinase kinase kinase 4(plus strand)

Molecule type Change Amino acid[Codon] SO Term
MAP3K4 transcript variant 3NM_001291958.1:c.N/AIntron Variant
MAP3K4 transcript variant 5NM_001301072.1:c.N/AIntron Variant
MAP3K4 transcript variant 1NM_005922.3:c.N/AIntron Variant
MAP3K4 transcript variant 2NM_006724.3:c.N/AIntron Variant
MAP3K4 transcript variant 4NR_120425.1:n.N/AIntron Variant
MAP3K4 transcript variant X1XM_005266989.2:c.N/AIntron Variant
MAP3K4 transcript variant X2XM_017010869.1:c.N/AIntron Variant
MAP3K4 transcript variant X3XR_001743422.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.492T=0.508
1000GenomesAmericanSub694C=0.900T=0.100
1000GenomesEast AsianSub1008C=0.650T=0.350
1000GenomesEuropeSub1006C=0.897T=0.103
1000GenomesGlobalStudy-wide5008C=0.719T=0.281
1000GenomesSouth AsianSub978C=0.790T=0.210
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.879T=0.121
The Genome Aggregation DatabaseAfricanSub8712C=0.570T=0.430
The Genome Aggregation DatabaseAmericanSub838C=0.900T=0.100
The Genome Aggregation DatabaseEast AsianSub1614C=0.615T=0.385
The Genome Aggregation DatabaseEuropeSub18486C=0.881T=0.118
The Genome Aggregation DatabaseGlobalStudy-wide29950C=0.777T=0.223
The Genome Aggregation DatabaseOtherSub300C=0.890T=0.110
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.728T=0.271
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.881T=0.119
PMID Title Author Journal
21956439Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.Zuo LNeuropsychopharmacology

P-Value

SNP ID p-value Traits Study
rs92951347E-06alcohol dependence21956439

eQTL of rs9295134 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs9295134 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6161431834161432030E067-18498
chr6161432113161432219E067-18309
chr6161432239161432472E067-18056
chr6161432580161433392E067-17136
chr6161499292161499426E06748764
chr6161433828161433922E068-16606
chr6161433948161434060E068-16468
chr6161434185161434235E068-16293
chr6161434638161434731E068-15797
chr6161434835161434997E068-15531
chr6161488975161489015E06838447
chr6161489263161489330E06838735
chr6161422619161422720E069-27808
chr6161432580161433392E069-17136
chr6161433828161433922E069-16606
chr6161433948161434060E069-16468
chr6161448806161448862E069-1666
chr6161448912161448962E069-1566
chr6161458878161460315E0698350
chr6161499292161499426E06948764
chr6161499428161499524E06948900
chr6161417036161417176E070-33352
chr6161417185161417681E070-32847
chr6161417705161417927E070-32601
chr6161422435161422548E070-27980
chr6161422619161422720E070-27808
chr6161431834161432030E070-18498
chr6161432580161433392E070-17136
chr6161487630161487823E07037102
chr6161487986161488101E07037458
chr6161488975161489015E07038447
chr6161489263161489330E07038735
chr6161489554161489895E07039026
chr6161489898161489975E07039370
chr6161490006161490056E07039478
chr6161431834161432030E071-18498
chr6161432113161432219E071-18309
chr6161432239161432472E071-18056
chr6161432580161433392E071-17136
chr6161433828161433922E071-16606
chr6161433948161434060E071-16468
chr6161458878161460315E0718350
chr6161488975161489015E07138447
chr6161489263161489330E07138735
chr6161489554161489895E07139026
chr6161432113161432219E072-18309
chr6161432239161432472E072-18056
chr6161432580161433392E072-17136
chr6161458878161460315E0728350
chr6161499292161499426E07248764
chr6161499428161499524E07248900
chr6161431575161431763E073-18765
chr6161431834161432030E073-18498
chr6161432113161432219E073-18309
chr6161432239161432472E073-18056
chr6161432580161433392E073-17136
chr6161434638161434731E073-15797
chr6161422435161422548E074-27980
chr6161422619161422720E074-27808
chr6161431834161432030E074-18498
chr6161432113161432219E074-18309
chr6161432239161432472E074-18056
chr6161432580161433392E074-17136
chr6161433828161433922E074-16606
chr6161433948161434060E074-16468
chr6161434835161434997E074-15531
chr6161458878161460315E0748350
chr6161488975161489015E07438447
chr6161489263161489330E07438735
chr6161489554161489895E07439026
chr6161499292161499426E07448764
chr6161432580161433392E081-17136
chr6161409521161409596E082-40932
chr6161417185161417681E082-32847
chr6161417705161417927E082-32601
chr6161418040161418100E082-32428
chr6161432580161433392E082-17136
chr6161488975161489015E08238447
chr6161489263161489330E08238735










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr6161411821161414219E067-36309
chr6161411821161414219E068-36309
chr6161411821161414219E069-36309
chr6161411821161414219E070-36309
chr6161411821161414219E071-36309
chr6161411821161414219E072-36309
chr6161411821161414219E073-36309
chr6161411821161414219E074-36309
chr6161411821161414219E081-36309
chr6161411821161414219E082-36309