rs9307383

Homo sapiens
C>T
ZGRF1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0410 (12296/29926,GnomAD)
C==0395 (11527/29118,TOPMED)
C==0277 (1387/5008,1000G)
C==0435 (1676/3854,ALSPAC)
C==0418 (1549/3708,TWINSUK)
chr4:112608678 (GRCh38.p7) (4q25)
AD
GWASdb2
1   publication(s)
See rs on genome
8 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.112608678C>T
GRCh37.p13 chr 4NC_000004.11:g.113529834C>T

Gene: ZGRF1, zinc finger GRF-type containing 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ZGRF1 transcript variant 1NM_018392.4:c.N/AIntron Variant
ZGRF1 transcript variant X1XM_005263115.3:c.N/AIntron Variant
ZGRF1 transcript variant X2XM_011532091.2:c.N/AIntron Variant
ZGRF1 transcript variant X3XM_011532092.2:c.N/AIntron Variant
ZGRF1 transcript variant X5XM_011532093.2:c.N/AIntron Variant
ZGRF1 transcript variant X6XM_011532094.2:c.N/AIntron Variant
ZGRF1 transcript variant X11XM_011532096.2:c.N/AIntron Variant
ZGRF1 transcript variant X4XM_017008369.1:c.N/AIntron Variant
ZGRF1 transcript variant X5XM_017008370.1:c.N/AIntron Variant
ZGRF1 transcript variant X7XM_017008371.1:c.N/AIntron Variant
ZGRF1 transcript variant X15XM_017008372.1:c.N/AIntron Variant
ZGRF1 transcript variant X16XM_017008373.1:c.N/AIntron Variant
ZGRF1 transcript variant X12XM_011532097.2:c.N/AGenic Upstream Transcript Variant
ZGRF1 transcript variant X13XM_011532098.2:c.N/AGenic Upstream Transcript Variant
ZGRF1 transcript variant X14XM_011532099.2:c.N/AGenic Upstream Transcript Variant
ZGRF1 transcript variant X10XR_001741282.1:n.N/AIntron Variant
ZGRF1 transcript variant X8XR_938763.1:n.N/AIntron Variant
ZGRF1 transcript variant X9XR_938764.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.386T=0.614
1000GenomesAmericanSub694C=0.260T=0.740
1000GenomesEast AsianSub1008C=0.060T=0.940
1000GenomesEuropeSub1006C=0.436T=0.564
1000GenomesGlobalStudy-wide5008C=0.277T=0.723
1000GenomesSouth AsianSub978C=0.200T=0.800
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.435T=0.565
The Genome Aggregation DatabaseAfricanSub8706C=0.391T=0.609
The Genome Aggregation DatabaseAmericanSub836C=0.260T=0.740
The Genome Aggregation DatabaseEast AsianSub1620C=0.049T=0.951
The Genome Aggregation DatabaseEuropeSub18462C=0.457T=0.542
The Genome Aggregation DatabaseGlobalStudy-wide29926C=0.410T=0.589
The Genome Aggregation DatabaseOtherSub302C=0.470T=0.530
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.395T=0.604
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.418T=0.582
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs93073830.000668alcohol dependence20201924

eQTL of rs9307383 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr4:113529834LARP7ENSG00000174720.11C>T2.1704e-3-28312Cerebellar_Hemisphere

meQTL of rs9307383 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4113559778113559852E06729944
chr4113559778113559852E06829944
chr4113559778113559852E06929944
chr4113559778113559852E07029944
chr4113559778113559852E07129944
chr4113554586113554987E07224752
chr4113559778113559852E07429944
chr4113559778113559852E08129944








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr4113557633113559114E06727799
chr4113557633113559114E06827799
chr4113557633113559114E06927799
chr4113557633113559114E07027799
chr4113557633113559114E07127799
chr4113557633113559114E07227799
chr4113557633113559114E07327799
chr4113557633113559114E07427799
chr4113557633113559114E08127799
chr4113557633113559114E08227799