rs9355870

Homo sapiens
A>G
MAP3K4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0214 (6426/29976,GnomAD)
G=0264 (7701/29118,TOPMED)
G=0273 (1365/5008,1000G)
G=0120 (464/3854,ALSPAC)
G=0119 (443/3708,TWINSUK)
chr6:161074626 (GRCh38.p7) (6q26)
AD
GWASdb2
1   publication(s)
See rs on genome
38 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.161074626A>G
GRCh37.p13 chr 6NC_000006.11:g.161495658A>G

Gene: MAP3K4, mitogen-activated protein kinase kinase kinase 4(plus strand)

Molecule type Change Amino acid[Codon] SO Term
MAP3K4 transcript variant 3NM_001291958.1:c.N/AIntron Variant
MAP3K4 transcript variant 5NM_001301072.1:c.N/AIntron Variant
MAP3K4 transcript variant 1NM_005922.3:c.N/AIntron Variant
MAP3K4 transcript variant 2NM_006724.3:c.N/AIntron Variant
MAP3K4 transcript variant 4NR_120425.1:n.N/AIntron Variant
MAP3K4 transcript variant X1XM_005266989.2:c.N/AIntron Variant
MAP3K4 transcript variant X2XM_017010869.1:c.N/AIntron Variant
MAP3K4 transcript variant X3XR_001743422.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.511G=0.489
1000GenomesAmericanSub694A=0.900G=0.100
1000GenomesEast AsianSub1008A=0.669G=0.331
1000GenomesEuropeSub1006A=0.895G=0.105
1000GenomesGlobalStudy-wide5008A=0.727G=0.273
1000GenomesSouth AsianSub978A=0.790G=0.210
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.880G=0.120
The Genome Aggregation DatabaseAfricanSub8716A=0.592G=0.408
The Genome Aggregation DatabaseAmericanSub838A=0.890G=0.110
The Genome Aggregation DatabaseEast AsianSub1616A=0.650G=0.350
The Genome Aggregation DatabaseEuropeSub18506A=0.882G=0.117
The Genome Aggregation DatabaseGlobalStudy-wide29976A=0.785G=0.214
The Genome Aggregation DatabaseOtherSub300A=0.890G=0.110
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.735G=0.264
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.881G=0.119
PMID Title Author Journal
21956439Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.Zuo LNeuropsychopharmacology

P-Value

SNP ID p-value Traits Study
rs93558707E-06alcohol dependence21956439

eQTL of rs9355870 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs9355870 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6161499292161499426E0673634
chr6161488975161489015E068-6643
chr6161489263161489330E068-6328
chr6161448806161448862E069-46796
chr6161448912161448962E069-46696
chr6161458878161460315E069-35343
chr6161499292161499426E0693634
chr6161499428161499524E0693770
chr6161522655161522846E06926997
chr6161487630161487823E070-7835
chr6161487986161488101E070-7557
chr6161488975161489015E070-6643
chr6161489263161489330E070-6328
chr6161489554161489895E070-5763
chr6161489898161489975E070-5683
chr6161490006161490056E070-5602
chr6161458878161460315E071-35343
chr6161488975161489015E071-6643
chr6161489263161489330E071-6328
chr6161489554161489895E071-5763
chr6161458878161460315E072-35343
chr6161499292161499426E0723634
chr6161499428161499524E0723770
chr6161503811161503865E0738153
chr6161458878161460315E074-35343
chr6161488975161489015E074-6643
chr6161489263161489330E074-6328
chr6161489554161489895E074-5763
chr6161499292161499426E0743634
chr6161530998161531048E08135340
chr6161531097161531364E08135439
chr6161531427161531477E08135769
chr6161531482161531662E08135824
chr6161531764161531924E08136106
chr6161531935161531995E08136277
chr6161531996161532160E08136338
chr6161488975161489015E082-6643
chr6161489263161489330E082-6328