rs9458121

Homo sapiens
A>G
MAP3K4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0084 (2518/29988,GnomAD)
G=0097 (2839/29118,TOPMED)
G=0083 (417/5008,1000G)
G=0060 (230/3854,ALSPAC)
G=0057 (213/3708,TWINSUK)
chr6:161101446 (GRCh38.p7) (6q26)
AD
GWASdb2
2   publication(s)
See rs on genome
111 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.161101446A>G
GRCh37.p13 chr 6NC_000006.11:g.161522478A>G

Gene: MAP3K4, mitogen-activated protein kinase kinase kinase 4(plus strand)

Molecule type Change Amino acid[Codon] SO Term
MAP3K4 transcript variant 3NM_001291958.1:c.N/AIntron Variant
MAP3K4 transcript variant 5NM_001301072.1:c.N/AIntron Variant
MAP3K4 transcript variant 1NM_005922.3:c.N/AIntron Variant
MAP3K4 transcript variant 2NM_006724.3:c.N/AIntron Variant
MAP3K4 transcript variant 4NR_120425.1:n.N/AIntron Variant
MAP3K4 transcript variant X1XM_005266989.2:c.N/AIntron Variant
MAP3K4 transcript variant X2XM_017010869.1:c.N/AIntron Variant
MAP3K4 transcript variant X3XR_001743422.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.825G=0.175
1000GenomesAmericanSub694A=0.960G=0.040
1000GenomesEast AsianSub1008A=0.977G=0.023
1000GenomesEuropeSub1006A=0.941G=0.059
1000GenomesGlobalStudy-wide5008A=0.917G=0.083
1000GenomesSouth AsianSub978A=0.920G=0.080
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.940G=0.060
The Genome Aggregation DatabaseAfricanSub8724A=0.858G=0.142
The Genome Aggregation DatabaseAmericanSub838A=0.950G=0.050
The Genome Aggregation DatabaseEast AsianSub1622A=0.976G=0.024
The Genome Aggregation DatabaseEuropeSub18502A=0.936G=0.063
The Genome Aggregation DatabaseGlobalStudy-wide29988A=0.916G=0.084
The Genome Aggregation DatabaseOtherSub302A=0.940G=0.060
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.902G=0.097
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.943G=0.057
PMID Title Author Journal
21529783A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Heath ACBiol Psychiatry
21956439Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.Zuo LNeuropsychopharmacology

P-Value

SNP ID p-value Traits Study
rs94581210.000001alcohol dependence21956439
rs94581210.000027alcoholism (heaviness of drinking)21529783

eQTL of rs9458121 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs9458121 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6161499292161499426E067-23052
chr6161555775161555853E06733297
chr6161556079161556156E06733601
chr6161556224161556290E06733746
chr6161556371161556427E06733893
chr6161556533161556583E06734055
chr6161556620161556797E06734142
chr6161559263161559689E06736785
chr6161559817161559897E06737339
chr6161559976161560066E06737498
chr6161560102161560234E06737624
chr6161488975161489015E068-33463
chr6161489263161489330E068-33148
chr6161555483161555734E06833005
chr6161555775161555853E06833297
chr6161556079161556156E06833601
chr6161556224161556290E06833746
chr6161556371161556427E06833893
chr6161556533161556583E06834055
chr6161556620161556797E06834142
chr6161556838161557078E06834360
chr6161557230161557392E06834752
chr6161557432161557681E06834954
chr6161557682161557744E06835204
chr6161560102161560234E06837624
chr6161499292161499426E069-23052
chr6161499428161499524E069-22954
chr6161522655161522846E069177
chr6161555483161555734E06933005
chr6161555775161555853E06933297
chr6161556079161556156E06933601
chr6161556224161556290E06933746
chr6161556371161556427E06933893
chr6161556533161556583E06934055
chr6161556620161556797E06934142
chr6161556838161557078E06934360
chr6161557230161557392E06934752
chr6161559263161559689E06936785
chr6161559817161559897E06937339
chr6161559976161560066E06937498
chr6161560102161560234E06937624
chr6161487630161487823E070-34655
chr6161487986161488101E070-34377
chr6161488975161489015E070-33463
chr6161489263161489330E070-33148
chr6161489554161489895E070-32583
chr6161489898161489975E070-32503
chr6161490006161490056E070-32422
chr6161488975161489015E071-33463
chr6161489263161489330E071-33148
chr6161489554161489895E071-32583
chr6161555775161555853E07133297
chr6161556079161556156E07133601
chr6161556224161556290E07133746
chr6161556371161556427E07133893
chr6161556533161556583E07134055
chr6161556620161556797E07134142
chr6161556838161557078E07134360
chr6161557230161557392E07134752
chr6161557432161557681E07134954
chr6161559263161559689E07136785
chr6161559817161559897E07137339
chr6161559976161560066E07137498
chr6161560102161560234E07137624
chr6161560510161560620E07138032
chr6161560811161561005E07138333
chr6161561024161561101E07138546
chr6161499292161499426E072-23052
chr6161499428161499524E072-22954
chr6161555483161555734E07233005
chr6161555775161555853E07233297
chr6161556079161556156E07233601
chr6161556224161556290E07233746
chr6161556371161556427E07233893
chr6161556533161556583E07234055
chr6161556620161556797E07234142
chr6161556838161557078E07234360
chr6161557932161557982E07235454
chr6161559263161559689E07236785
chr6161559976161560066E07237498
chr6161560102161560234E07237624
chr6161560510161560620E07238032
chr6161503811161503865E073-18613
chr6161488975161489015E074-33463
chr6161489263161489330E074-33148
chr6161489554161489895E074-32583
chr6161499292161499426E074-23052
chr6161555775161555853E07433297
chr6161556079161556156E07433601
chr6161556224161556290E07433746
chr6161556371161556427E07433893
chr6161556533161556583E07434055
chr6161556620161556797E07434142
chr6161556838161557078E07434360
chr6161557230161557392E07434752
chr6161557432161557681E07434954
chr6161558042161558209E07435564
chr6161559263161559689E07436785
chr6161559817161559897E07437339
chr6161559976161560066E07437498
chr6161560102161560234E07437624
chr6161560510161560620E07438032
chr6161530998161531048E0818520
chr6161531097161531364E0818619
chr6161531427161531477E0818949
chr6161531482161531662E0819004
chr6161531764161531924E0819286
chr6161531935161531995E0819457
chr6161531996161532160E0819518
chr6161488975161489015E082-33463
chr6161489263161489330E082-33148