rs9459418

Homo sapiens
C>A
PDE10A : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0314 (9404/29918,GnomAD)
A=0345 (10047/29118,TOPMED)
A=0318 (1593/5008,1000G)
A=0275 (1061/3854,ALSPAC)
A=0280 (1040/3708,TWINSUK)
chr6:165454303 (GRCh38.p7) (6q27)
AD
GWASdb2
1   publication(s)
See rs on genome
21 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.165454303C>A
GRCh37.p13 chr 6NC_000006.11:g.165867791C>A
PDE10A RefSeqGeneNG_031878.2:g.212798G>T

Gene: PDE10A, phosphodiesterase 10A(minus strand)

Molecule type Change Amino acid[Codon] SO Term
PDE10A transcript variant 1NM_001130690.2:c.N/AIntron Variant
PDE10A transcript variant 2NM_006661.3:c.N/AIntron Variant
PDE10A transcript variant X4XM_006715321.3:c.N/AIntron Variant
PDE10A transcript variant X1XM_011535387.2:c.N/AIntron Variant
PDE10A transcript variant X3XM_011535388.2:c.N/AIntron Variant
PDE10A transcript variant X8XM_011535393.2:c.N/AIntron Variant
PDE10A transcript variant X2XM_017010194.1:c.N/AIntron Variant
PDE10A transcript variant X5XM_017010195.1:c.N/AIntron Variant
PDE10A transcript variant X6XM_017010196.1:c.N/AIntron Variant
PDE10A transcript variant X7XM_017010197.1:c.N/AIntron Variant
PDE10A transcript variant X9XR_001743121.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.527A=0.473
1000GenomesAmericanSub694C=0.640A=0.360
1000GenomesEast AsianSub1008C=0.779A=0.221
1000GenomesEuropeSub1006C=0.723A=0.277
1000GenomesGlobalStudy-wide5008C=0.682A=0.318
1000GenomesSouth AsianSub978C=0.780A=0.220
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.725A=0.275
The Genome Aggregation DatabaseAfricanSub8694C=0.534A=0.466
The Genome Aggregation DatabaseAmericanSub838C=0.690A=0.310
The Genome Aggregation DatabaseEast AsianSub1618C=0.763A=0.237
The Genome Aggregation DatabaseEuropeSub18466C=0.749A=0.250
The Genome Aggregation DatabaseGlobalStudy-wide29918C=0.685A=0.314
The Genome Aggregation DatabaseOtherSub302C=0.710A=0.290
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.655A=0.345
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.720A=0.280
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs94594180.000386alcohol dependence21314694

eQTL of rs9459418 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs9459418 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6165895404165895969E06827613
chr6165896236165896286E06828445
chr6165896497165896553E06828706
chr6165899864165900137E06832073
chr6165900158165900263E06832367
chr6165873628165873870E0695837
chr6165873628165873870E0705837
chr6165898128165898319E07030337
chr6165898358165898414E07030567
chr6165899864165900137E07032073
chr6165900158165900263E07032367
chr6165853437165854009E071-13782
chr6165899864165900137E07132073
chr6165899864165900137E07432073
chr6165900158165900263E07432367
chr6165818170165818346E081-49445
chr6165873283165873377E0815492
chr6165873628165873870E0815837
chr6165818170165818346E082-49445
chr6165899864165900137E08232073
chr6165900158165900263E08232367