rs964170

Homo sapiens
G>T
ARHGAP10 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0246 (7379/29918,GnomAD)
G==0363 (10570/29118,TOPMED)
G==0320 (1601/5008,1000G)
G==0058 (225/3854,ALSPAC)
G==0055 (204/3708,TWINSUK)
chr4:147774805 (GRCh38.p7) (4q31.23)
ND
GWASdb2
1   publication(s)
See rs on genome
33 Enhancers around
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.147774805G>T
GRCh37.p13 chr 4NC_000004.11:g.148695956G>T

Gene: ARHGAP10, Rho GTPase activating protein 10(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ARHGAP10 transcriptNM_024605.3:c.N/AIntron Variant
ARHGAP10 transcript variant X1XM_005263215.3:c.N/AIntron Variant
ARHGAP10 transcript variant X2XM_017008602.1:c.N/AIntron Variant
ARHGAP10 transcript variant X3XR_001741324.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.821T=0.179
1000GenomesAmericanSub694G=0.140T=0.860
1000GenomesEast AsianSub1008G=0.147T=0.853
1000GenomesEuropeSub1006G=0.063T=0.937
1000GenomesGlobalStudy-wide5008G=0.320T=0.680
1000GenomesSouth AsianSub978G=0.210T=0.790
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.058T=0.942
The Genome Aggregation DatabaseAfricanSub8694G=0.694T=0.306
The Genome Aggregation DatabaseAmericanSub836G=0.140T=0.860
The Genome Aggregation DatabaseEast AsianSub1614G=0.136T=0.864
The Genome Aggregation DatabaseEuropeSub18472G=0.053T=0.946
The Genome Aggregation DatabaseGlobalStudy-wide29918G=0.246T=0.753
The Genome Aggregation DatabaseOtherSub302G=0.090T=0.910
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.363T=0.637
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.055T=0.945
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs9641704.43E-08Nicotine dependence (smoking)20158304
rs9641700.00000149Comorbid alcohol and nicotine dependence20158304

eQTL of rs964170 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs964170 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4148676713148677287E067-18669
chr4148706298148706613E06810342
chr4148706684148706904E06810728
chr4148729292148729365E06833336
chr4148729728148729817E06833772
chr4148737655148737815E06841699
chr4148737876148737949E06841920
chr4148737953148738016E06841997
chr4148738054148738175E06842098
chr4148742192148742577E06846236
chr4148742781148743119E06846825
chr4148743153148743973E06847197
chr4148671037148671124E069-24832
chr4148671037148671124E070-24832
chr4148671290148671358E070-24598
chr4148671398148671460E070-24496
chr4148723052148723261E07027096
chr4148723387148723442E07027431
chr4148677893148678008E071-17948
chr4148706298148706613E07110342
chr4148706684148706904E07110728
chr4148734663148734876E07138707
chr4148737080148737197E07141124
chr4148675140148675617E072-20339
chr4148706298148706613E07210342
chr4148706684148706904E07210728
chr4148675140148675617E073-20339
chr4148676713148677287E073-18669
chr4148701591148701723E0735635
chr4148701746148701933E0735790
chr4148671037148671124E081-24832
chr4148671290148671358E081-24598
chr4148671398148671460E081-24496








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr4148652166148654713E067-41243
chr4148652166148654713E068-41243
chr4148652166148654713E069-41243
chr4148652166148654713E071-41243
chr4148652166148654713E072-41243
chr4148652166148654713E073-41243
chr4148652166148654713E074-41243
chr4148652166148654713E082-41243