rs9822871

Homo sapiens
C>T
HRH1 : Intron Variant
LOC102723663 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0242 (7262/29954,GnomAD)
T=0225 (6557/29118,TOPMED)
T=0162 (812/5008,1000G)
T=0318 (1227/3854,ALSPAC)
T=0299 (1108/3708,TWINSUK)
chr3:11197680 (GRCh38.p7) (3p25.3)
AD
GWASdb2
1   publication(s)
See rs on genome
63 Enhancers around
17 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.11197680C>T
GRCh37.p13 chr 3NC_000003.11:g.11239366C>T

Gene: HRH1, histamine receptor H1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
HRH1 transcript variant 2NM_001098212.1:c.N/AIntron Variant
HRH1 transcript variant 1NM_001098213.1:c.N/AIntron Variant
HRH1 transcript variant 4NM_000861.3:c.N/AGenic Upstream Transcript Variant
HRH1 transcript variant 3NM_001098211.1:c.N/AGenic Upstream Transcript Variant
HRH1 transcript variant X3XM_011533653.2:c.N/AIntron Variant
HRH1 transcript variant X4XM_017006284.1:c.N/AIntron Variant
HRH1 transcript variant X1XM_011533652.1:c.N/AGenic Upstream Transcript Variant
HRH1 transcript variant X2XM_017006283.1:c.N/AGenic Upstream Transcript Variant

Gene: LOC102723663, uncharacterized LOC102723663(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC102723663 transcript variant X1XR_001740595.1:n.N/AIntron Variant
LOC102723663 transcript variant X2XR_001740596.1:n.N/AIntron Variant
LOC102723663 transcript variant X3XR_001740597.1:n.N/AIntron Variant
LOC102723663 transcript variant X4XR_001740598.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.904T=0.096
1000GenomesAmericanSub694C=0.800T=0.200
1000GenomesEast AsianSub1008C=0.832T=0.168
1000GenomesEuropeSub1006C=0.715T=0.285
1000GenomesGlobalStudy-wide5008C=0.838T=0.162
1000GenomesSouth AsianSub978C=0.910T=0.090
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.682T=0.318
The Genome Aggregation DatabaseAfricanSub8724C=0.865T=0.135
The Genome Aggregation DatabaseAmericanSub838C=0.760T=0.240
The Genome Aggregation DatabaseEast AsianSub1616C=0.840T=0.160
The Genome Aggregation DatabaseEuropeSub18476C=0.698T=0.301
The Genome Aggregation DatabaseGlobalStudy-wide29954C=0.757T=0.242
The Genome Aggregation DatabaseOtherSub300C=0.790T=0.210
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.774T=0.225
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.701T=0.299
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs98228716.31E-05alcohol dependence21703634

eQTL of rs9822871 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs9822871 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr31123679611237228E067-2138
chr31123727011237366E067-2000
chr31123750611238046E067-1320
chr31124289711243158E0673531
chr31124652611246983E0677160
chr31121101211211103E068-28263
chr31121127111211451E068-27915
chr31123679611237228E068-2138
chr31123727011237366E068-2000
chr31123750611238046E068-1320
chr31121182011212119E069-27247
chr31122521611225324E069-14042
chr31122594411225994E069-13372
chr31123679611237228E069-2138
chr31123727011237366E069-2000
chr31124289711243158E0693531
chr31124328411243548E0693918
chr31124652611246983E0697160
chr31125320811253299E06913842
chr31125337311253552E06914007
chr31124289711243158E0703531
chr31124328411243548E0703918
chr31124356211243671E0704196
chr31124652611246983E0707160
chr31125292211253110E07013556
chr31125320811253299E07013842
chr31125337311253552E07014007
chr31120107211201641E071-37725
chr31120675111206801E071-32565
chr31122719011228285E071-11081
chr31123679611237228E071-2138
chr31123727011237366E071-2000
chr31124289711243158E0713531
chr31124328411243548E0713918
chr31120675111206801E072-32565
chr31120725711207551E072-31815
chr31121101211211103E072-28263
chr31121127111211451E072-27915
chr31122719011228285E072-11081
chr31123679611237228E072-2138
chr31123727011237366E072-2000
chr31123750611238046E072-1320
chr31124652611246983E0727160
chr31120639011206631E073-32735
chr31121060511210665E073-28701
chr31121101211211103E073-28263
chr31121127111211451E073-27915
chr31121182011212119E073-27247
chr31122521611225324E073-14042
chr31122719011228285E073-11081
chr31123679611237228E073-2138
chr31123727011237366E073-2000
chr31123750611238046E073-1320
chr31124289711243158E0733531
chr31124652611246983E0737160
chr31125320811253299E07313842
chr31125337311253552E07314007
chr31120940411209510E074-29856
chr31123679611237228E074-2138
chr31123727011237366E074-2000
chr31123750611238046E074-1320
chr31124652611246983E0817160
chr31124652611246983E0827160










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr31119604211197536E067-41830
chr31119810011198150E067-41216
chr31119580911195875E068-43491
chr31119604211197536E068-41830
chr31119580911195875E069-43491
chr31119604211197536E069-41830
chr31119810011198150E069-41216
chr31119580911195875E070-43491
chr31119580911195875E071-43491
chr31119580911195875E072-43491
chr31119604211197536E072-41830
chr31119810011198150E072-41216
chr31119580911195875E073-43491
chr31119604211197536E073-41830
chr31119810011198150E073-41216
chr31119604211197536E074-41830
chr31119580911195875E082-43491