rs9857773

Homo sapiens
C>A
WWTR1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0469 (14021/29852,GnomAD)
C==0471 (13718/29118,TOPMED)
A=0462 (2313/5008,1000G)
C==0374 (1442/3854,ALSPAC)
C==0359 (1333/3708,TWINSUK)
chr3:149626828 (GRCh38.p7) (3q25.1)
AD
GWASdb2
1   publication(s)
See rs on genome

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.149626828C>A
GRCh37.p13 chr 3NC_000003.11:g.149344615C>A

Gene: WWTR1, WW domain containing transcription regulator 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
WWTR1 transcript variant 2NM_001168278.1:c.N/AIntron Variant
WWTR1 transcript variant 3NM_001168280.1:c.N/AIntron Variant
WWTR1 transcript variant 1NM_015472.4:c.N/AIntron Variant
WWTR1 transcript variant X1XM_017006121.1:c.N/AIntron Variant
WWTR1 transcript variant X1XM_017006122.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.711A=0.289
1000GenomesAmericanSub694C=0.520A=0.480
1000GenomesEast AsianSub1008C=0.572A=0.428
1000GenomesEuropeSub1006C=0.359A=0.641
1000GenomesGlobalStudy-wide5008C=0.538A=0.462
1000GenomesSouth AsianSub978C=0.470A=0.530
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.374A=0.626
The Genome Aggregation DatabaseAfricanSub8678C=0.635A=0.365
The Genome Aggregation DatabaseAmericanSub834C=0.530A=0.470
The Genome Aggregation DatabaseEast AsianSub1612C=0.639A=0.361
The Genome Aggregation DatabaseEuropeSub18426C=0.377A=0.622
The Genome Aggregation DatabaseGlobalStudy-wide29852C=0.469A=0.530
The Genome Aggregation DatabaseOtherSub302C=0.300A=0.700
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.471A=0.528
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.359A=0.641
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs98577730.00047alcohol dependence20201924

eQTL of rs9857773 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs9857773 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3149298848149298917E067-45698
chr3149304761149304956E067-39659
chr3149308522149308779E067-35836
chr3149327988149328641E067-15974
chr3149335966149336209E067-8406
chr3149348580149349007E0673965
chr3149355456149355618E06710841
chr3149355674149355744E06711059
chr3149355900149356028E06711285
chr3149359059149359262E06714444
chr3149359298149359436E06714683
chr3149294930149295408E068-49207
chr3149298625149298796E068-45819
chr3149298848149298917E068-45698
chr3149299011149300464E068-44151
chr3149301475149301622E068-42993
chr3149301660149301744E068-42871
chr3149301816149301977E068-42638
chr3149302130149302295E068-42320
chr3149308522149308779E068-35836
chr3149309002149309130E068-35485
chr3149310425149311137E068-33478
chr3149311212149311525E068-33090
chr3149311682149311773E068-32842
chr3149319629149319692E068-24923
chr3149319995149320047E068-24568
chr3149320179149320366E068-24249
chr3149320699149320775E068-23840
chr3149320919149321192E068-23423
chr3149321301149321599E068-23016
chr3149321616149321738E068-22877
chr3149322018149322188E068-22427
chr3149322217149322794E068-21821
chr3149327401149327760E068-16855
chr3149327808149327920E068-16695
chr3149327988149328641E068-15974
chr3149328967149329083E068-15532
chr3149329116149329172E068-15443
chr3149330422149330466E068-14149
chr3149330921149331104E068-13511
chr3149335056149335177E068-9438
chr3149335966149336209E068-8406
chr3149348440149348494E0683825
chr3149348580149349007E0683965
chr3149352010149352163E0687395
chr3149352487149352670E0687872
chr3149352706149352750E0688091
chr3149355456149355618E06810841
chr3149355674149355744E06811059
chr3149355900149356028E06811285
chr3149359059149359262E06814444
chr3149359298149359436E06814683
chr3149359601149359704E06814986
chr3149360894149360994E06816279
chr3149361506149361610E06816891
chr3149361904149361996E06817289
chr3149365790149365908E06821175
chr3149365976149366098E06821361
chr3149301816149301977E069-42638
chr3149302130149302295E069-42320
chr3149308522149308779E069-35836
chr3149327401149327760E069-16855
chr3149327808149327920E069-16695
chr3149327988149328641E069-15974
chr3149328967149329083E069-15532
chr3149329116149329172E069-15443
chr3149348440149348494E0693825
chr3149348580149349007E0693965
chr3149359059149359262E06914444
chr3149359298149359436E06914683
chr3149366254149366737E06921639
chr3149371165149371209E06926550
chr3149371343149371480E06926728
chr3149371518149371568E06926903
chr3149371641149371731E06927026
chr3149310425149311137E070-33478
chr3149311212149311525E070-33090
chr3149311682149311773E070-32842
chr3149312316149312469E070-32146
chr3149319995149320047E070-24568
chr3149320179149320366E070-24249
chr3149320699149320775E070-23840
chr3149320919149321192E070-23423
chr3149321301149321599E070-23016
chr3149321616149321738E070-22877
chr3149322018149322188E070-22427
chr3149322217149322794E070-21821
chr3149327808149327920E070-16695
chr3149327988149328641E070-15974
chr3149355456149355618E07010841
chr3149355674149355744E07011059
chr3149355900149356028E07011285
chr3149297044149297246E071-47369
chr3149297582149298303E071-46312
chr3149299011149300464E071-44151
chr3149301475149301622E071-42993
chr3149301660149301744E071-42871
chr3149301816149301977E071-42638
chr3149302130149302295E071-42320
chr3149302510149302562E071-42053
chr3149304761149304956E071-39659
chr3149304963149305084E071-39531
chr3149310425149311137E071-33478
chr3149311212149311525E071-33090
chr3149320919149321192E071-23423
chr3149321301149321599E071-23016
chr3149321616149321738E071-22877
chr3149322018149322188E071-22427
chr3149322217149322794E071-21821
chr3149322843149322937E071-21678
chr3149327808149327920E071-16695
chr3149327988149328641E071-15974
chr3149328967149329083E071-15532
chr3149329116149329172E071-15443
chr3149335056149335177E071-9438
chr3149335966149336209E071-8406
chr3149336535149336957E071-7658
chr3149348440149348494E0713825
chr3149348580149349007E0713965
chr3149351800149351882E0717185
chr3149352010149352163E0717395
chr3149352487149352670E0717872
chr3149352706149352750E0718091
chr3149355456149355618E07110841
chr3149355674149355744E07111059
chr3149355900149356028E07111285
chr3149359059149359262E07114444
chr3149359298149359436E07114683
chr3149359601149359704E07114986
chr3149361304149361362E07116689
chr3149361904149361996E07117289
chr3149365976149366098E07121361
chr3149366254149366737E07121639
chr3149371518149371568E07126903
chr3149327988149328641E072-15974
chr3149348440149348494E0723825
chr3149348580149349007E0723965
chr3149359059149359262E07214444
chr3149359298149359436E07214683
chr3149295604149296016E073-48599
chr3149299011149300464E073-44151
chr3149320179149320366E073-24249
chr3149320699149320775E073-23840
chr3149320919149321192E073-23423
chr3149322018149322188E073-22427
chr3149322217149322794E073-21821
chr3149335966149336209E073-8406
chr3149348440149348494E0733825
chr3149352487149352670E0737872
chr3149352706149352750E0738091
chr3149365976149366098E07321361
chr3149366254149366737E07321639
chr3149371165149371209E07326550
chr3149371343149371480E07326728
chr3149371518149371568E07326903
chr3149377243149377299E07332628
chr3149377526149377609E07332911
chr3149301475149301622E074-42993
chr3149301660149301744E074-42871
chr3149301816149301977E074-42638
chr3149310425149311137E074-33478
chr3149327988149328641E074-15974
chr3149328967149329083E074-15532
chr3149329116149329172E074-15443
chr3149348440149348494E0743825
chr3149348580149349007E0743965
chr3149352487149352670E0747872
chr3149352706149352750E0748091
chr3149358620149359026E07414005
chr3149359059149359262E07414444
chr3149359298149359436E07414683
chr3149295604149296016E081-48599
chr3149296278149296328E081-48287
chr3149297044149297246E081-47369
chr3149297582149298303E081-46312
chr3149311682149311773E081-32842
chr3149318517149318864E081-25751
chr3149327401149327760E081-16855
chr3149327808149327920E081-16695
chr3149327988149328641E081-15974
chr3149295604149296016E082-48599
chr3149296278149296328E082-48287
chr3149297044149297246E082-47369
chr3149299011149300464E082-44151
chr3149310425149311137E082-33478
chr3149311212149311525E082-33090
chr3149311682149311773E082-32842
chr3149318517149318864E082-25751
chr3149327988149328641E082-15974
chr3149328967149329083E082-15532
chr3149329116149329172E082-15443
chr3149355900149356028E08211285










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr3149373943149377198E06729328
chr3149373321149373699E06828706
chr3149373702149373835E06829087
chr3149373943149377198E06829328
chr3149373702149373835E06929087
chr3149373943149377198E06929328
chr3149373321149373699E07028706
chr3149373702149373835E07029087
chr3149373321149373699E07128706
chr3149373702149373835E07129087
chr3149373943149377198E07129328
chr3149373321149373699E07228706
chr3149373702149373835E07229087
chr3149373943149377198E07229328
chr3149373321149373699E07328706
chr3149373702149373835E07329087
chr3149373943149377198E07329328
chr3149373943149377198E07429328
chr3149373943149377198E08229328