rs9874357

Homo sapiens
T>C
AADACL2-AS1 : Intron Variant
LOC105374160 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0189 (5670/29870,GnomAD)
C=0180 (900/5008,1000G)
C=0200 (769/3854,ALSPAC)
C=0213 (789/3708,TWINSUK)
chr3:151796917 (GRCh38.p7) (3q25.1)
AD
GWASdb2
1   publication(s)
See rs on genome
2 Enhancers around
5 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.151796917T>C
GRCh37.p13 chr 3NC_000003.11:g.151514705T>C

Gene: AADACL2-AS1, AADACL2 antisense RNA 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
AADACL2-AS1 transcript variant 1NR_110202.1:n.N/AIntron Variant
AADACL2-AS1 transcript variant 2NR_110203.1:n.N/AIntron Variant

Gene: LOC105374160, uncharacterized LOC105374160(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105374160 transcript variant X1XR_924585.2:n.N/AIntron Variant
LOC105374160 transcript variant X2XR_924586.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.855C=0.145
1000GenomesAmericanSub694T=0.830C=0.170
1000GenomesEast AsianSub1008T=0.902C=0.098
1000GenomesEuropeSub1006T=0.783C=0.217
1000GenomesGlobalStudy-wide5008T=0.820C=0.180
1000GenomesSouth AsianSub978T=0.720C=0.280
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.800C=0.200
The Genome Aggregation DatabaseAfricanSub8714T=0.833C=0.167
The Genome Aggregation DatabaseAmericanSub838T=0.790C=0.210
The Genome Aggregation DatabaseEast AsianSub1618T=0.890C=0.110
The Genome Aggregation DatabaseEuropeSub18398T=0.794C=0.205
The Genome Aggregation DatabaseGlobalStudy-wide29870T=0.810C=0.189
The Genome Aggregation DatabaseOtherSub302T=0.700C=0.300
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.787C=0.213
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs98743570.00036alcohol dependence20201924

eQTL of rs9874357 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs9874357 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3151553937151554301E06839232
chr3151554746151555335E06840041

Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr3151556712151557033E06842007
chr3151556712151557033E06942007
chr3151556712151557033E07142007
chr3151556712151557033E07242007
chr3151556712151557033E08142007