rs9876768

Homo sapiens
T>C
PLCL2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0193 (5783/29900,GnomAD)
C=0147 (4302/29118,TOPMED)
C=0144 (722/5008,1000G)
C=0201 (773/3854,ALSPAC)
C=0217 (804/3708,TWINSUK)
chr3:17008473 (GRCh38.p7) (3p24.3)
AD
GWASdb2
1   publication(s)
See rs on genome
75 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.17008473T>C
GRCh37.p13 chr 3NC_000003.11:g.17049965T>C

Gene: PLCL2, phospholipase C like 2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
PLCL2 transcript variant 1NM_001144382.1:c.N/AIntron Variant
PLCL2 transcript variant 2NM_015184.5:c.N/AIntron Variant
PLCL2 transcript variant X4XM_006713073.3:c.N/AIntron Variant
PLCL2 transcript variant X1XM_017006022.1:c.N/AIntron Variant
PLCL2 transcript variant X2XM_017006023.1:c.N/AIntron Variant
PLCL2 transcript variant X3XM_017006024.1:c.N/AIntron Variant
PLCL2 transcript variant X5XM_017006025.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.925C=0.075
1000GenomesAmericanSub694T=0.720C=0.280
1000GenomesEast AsianSub1008T=0.918C=0.082
1000GenomesEuropeSub1006T=0.787C=0.213
1000GenomesGlobalStudy-wide5008T=0.856C=0.144
1000GenomesSouth AsianSub978T=0.870C=0.130
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.799C=0.201
The Genome Aggregation DatabaseAfricanSub8696T=0.899C=0.101
The Genome Aggregation DatabaseAmericanSub838T=0.710C=0.290
The Genome Aggregation DatabaseEast AsianSub1606T=0.904C=0.096
The Genome Aggregation DatabaseEuropeSub18458T=0.758C=0.241
The Genome Aggregation DatabaseGlobalStudy-wide29900T=0.806C=0.193
The Genome Aggregation DatabaseOtherSub302T=0.810C=0.190
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.852C=0.147
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.783C=0.217
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs98767680.000505alcohol dependence20201924

eQTL of rs9876768 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs9876768 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr31704791517048320E067-1645
chr31705324317053293E0673278
chr31705335517053405E0673390
chr31705359417053658E0673629
chr31705465617054916E0674691
chr31705522917055377E0675264
chr31708049317080601E06730528
chr31708065817080768E06730693
chr31708081417080983E06730849
chr31708106117081488E06731096
chr31708171017081819E06731745
chr31708191417082577E06731949
chr31703591417036006E068-13959
chr31705431317054363E0684348
chr31705465617054916E0684691
chr31705522917055377E0685264
chr31707400417074212E06824039
chr31707423517074296E06824270
chr31707457417074668E06824609
chr31707472517074791E06824760
chr31708106117081488E06831096
chr31708171017081819E06831745
chr31708191417082577E06831949
chr31708272417082816E06832759
chr31708049317080601E06930528
chr31708171017081819E06931745
chr31708191417082577E06931949
chr31705465617054916E0704691
chr31707970717079894E07029742
chr31708049317080601E07030528
chr31708065817080768E07030693
chr31708171017081819E07031745
chr31708272417082816E07032759
chr31708556317085721E07035598
chr31708579617085887E07035831
chr31704015417040346E071-9619
chr31708106117081488E07131096
chr31708171017081819E07131745
chr31708191417082577E07131949
chr31705324317053293E0723278
chr31705335517053405E0723390
chr31705359417053658E0723629
chr31708106117081488E07231096
chr31708171017081819E07231745
chr31708191417082577E07231949
chr31708049317080601E07330528
chr31708065817080768E07330693
chr31708081417080983E07330849
chr31708106117081488E07331096
chr31708171017081819E07331745
chr31708191417082577E07331949
chr31708579617085887E07335831
chr31709682417097546E07346859
chr31709758117097696E07347616
chr31703186617031956E074-18009
chr31705324317053293E0743278
chr31705335517053405E0743390
chr31708049317080601E07430528
chr31708065817080768E07430693
chr31708081417080983E07430849
chr31708106117081488E07431096
chr31708171017081819E07431745
chr31708191417082577E07431949
chr31703591417036006E081-13959
chr31707508617075299E08125121
chr31707534817075560E08125383
chr31703591417036006E082-13959
chr31703645717036517E082-13448
chr31703682817036965E082-13000
chr31703713817037425E082-12540
chr31707970717079894E08229742
chr31708081417080983E08230849
chr31708106117081488E08231096
chr31708171017081819E08231745
chr31708191417082577E08231949