rs9935088

Homo sapiens
A>G
WWOX : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0250 (7471/29796,GnomAD)
G=0273 (7956/29118,TOPMED)
G=0358 (1795/5008,1000G)
G=0136 (523/3854,ALSPAC)
G=0137 (509/3708,TWINSUK)
chr16:78945618 (GRCh38.p7) (16q23.1)
AD
GWASdb2
1   publication(s)
See rs on genome
94 Enhancers around
6 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.78945618A>G
GRCh37.p13 chr 16NC_000016.9:g.78979515A>G
WWOX RefSeqGeneNG_011698.1:g.850965A>G

Gene: WWOX, WW domain containing oxidoreductase(plus strand)

Molecule type Change Amino acid[Codon] SO Term
WWOX transcript variant 4NM_001291997.1:c.N/AIntron Variant
WWOX transcript variant 1NM_016373.3:c.N/AIntron Variant
WWOX transcript variant 2NM_130791.3:c.N/AGenic Downstream Transcript Variant
WWOX transcript variant 3NR_120435.1:n.N/AGenic Downstream Transcript Variant
WWOX transcript variant 5NR_120436.1:n.N/AGenic Downstream Transcript Variant
WWOX transcript variant X2XM_011523103.2:c.N/AIntron Variant
WWOX transcript variant X6XM_017023279.1:c.N/AIntron Variant
WWOX transcript variant X1XM_011523101.2:c.N/AGenic Downstream Transcript Variant
WWOX transcript variant X3XM_011523104.2:c.N/AGenic Downstream Transcript Variant
WWOX transcript variant X5XM_011523105.2:c.N/AGenic Downstream Transcript Variant
WWOX transcript variant X4XM_017023278.1:c.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.538G=0.462
1000GenomesAmericanSub694A=0.640G=0.360
1000GenomesEast AsianSub1008A=0.583G=0.417
1000GenomesEuropeSub1006A=0.851G=0.149
1000GenomesGlobalStudy-wide5008A=0.642G=0.358
1000GenomesSouth AsianSub978A=0.630G=0.370
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.864G=0.136
The Genome Aggregation DatabaseAfricanSub8684A=0.588G=0.412
The Genome Aggregation DatabaseAmericanSub830A=0.630G=0.370
The Genome Aggregation DatabaseEast AsianSub1610A=0.579G=0.421
The Genome Aggregation DatabaseEuropeSub18372A=0.843G=0.156
The Genome Aggregation DatabaseGlobalStudy-wide29796A=0.749G=0.250
The Genome Aggregation DatabaseOtherSub300A=0.880G=0.120
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.726G=0.273
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.863G=0.137
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs99350880.000788alcohol dependence21314694

eQTL of rs9935088 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs9935088 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr167900573679006281E06726221
chr167901855379019395E06739038
chr167902270079022990E06743185
chr167902324879023388E06743733
chr167902356879024064E06744053
chr167902411679024560E06744601
chr167902460979024895E06745094
chr167902493179025033E06745416
chr167896107978961256E068-18259
chr167900573679006281E06826221
chr167901832679018547E06838811
chr167902270079022990E06843185
chr167902324879023388E06843733
chr167902356879024064E06844053
chr167902411679024560E06844601
chr167902460979024895E06845094
chr167902493179025033E06845416
chr167902512279025183E06845607
chr167902564179025691E06846126
chr167902570679025788E06846191
chr167902235579022663E06942840
chr167902270079022990E06943185
chr167902324879023388E06943733
chr167902356879024064E06944053
chr167902411679024560E06944601
chr167902460979024895E06945094
chr167902493179025033E06945416
chr167894924278949292E070-30223
chr167894975078949960E070-29555
chr167894997478950375E070-29140
chr167895066678950720E070-28795
chr167895087378950926E070-28589
chr167895095578951196E070-28319
chr167896086678960963E070-18552
chr167896107978961256E070-18259
chr167898055478980691E0701039
chr167898070578980844E0701190
chr167898099178981031E0701476
chr167898127778981571E0701762
chr167899125878991519E07011743
chr167900247179002531E07022956
chr167900269379002757E07023178
chr167900282079002935E07023305
chr167900300579003065E07023490
chr167900743179007484E07027916
chr167900753379007577E07028018
chr167901583079016593E07036315
chr167901681279016904E07037297
chr167901855379019395E07039038
chr167902411679024560E07044601
chr167902904579029133E07049530
chr167902920879029286E07049693
chr167902235579022663E07142840
chr167902270079022990E07143185
chr167902324879023388E07143733
chr167902356879024064E07144053
chr167902411679024560E07144601
chr167902460979024895E07145094
chr167902493179025033E07145416
chr167900573679006281E07226221
chr167901973679020388E07240221
chr167902270079022990E07243185
chr167902324879023388E07243733
chr167902356879024064E07244053
chr167902411679024560E07244601
chr167902460979024895E07245094
chr167902493179025033E07245416
chr167902512279025183E07245607
chr167901855379019395E07339038
chr167902411679024560E07344601
chr167902460979024895E07345094
chr167902493179025033E07345416
chr167902512279025183E07345607
chr167899125878991519E07411743
chr167900573679006281E07426221
chr167901832679018547E07438811
chr167902235579022663E07442840
chr167902270079022990E07443185
chr167902324879023388E07443733
chr167902356879024064E07444053
chr167902411679024560E07444601
chr167902460979024895E07445094
chr167902493179025033E07445416
chr167900522579005275E08125710
chr167900544779005503E08125932
chr167900552979005579E08126014
chr167900573679006281E08126221
chr167901583079016593E08136315
chr167901855379019395E08139038
chr167902709979027604E08147584
chr167902779479027869E08148279
chr167902904579029133E08149530
chr167902920879029286E08149693
chr167900573679006281E08226221










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr167900674879007366E06727233
chr167900674879007366E06827233
chr167900674879007366E06927233
chr167900674879007366E07027233
chr167900674879007366E07127233
chr167900674879007366E07227233