rs9936994

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

ZCCHC14 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0292 (8739/29912,GnomAD)
A=0359 (10468/29118,TOPMED)
A=0372 (1862/5008,1000G)
A=0131 (505/3854,ALSPAC)
A=0131 (486/3708,TWINSUK)

Position: chr16:87469209 (GRCh38.p7) (16q24.2)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 389 Enhancers around

Promoter: 45 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 16	NC_000016.10:g.87469209G>A
GRCh37.p13 chr 16	NC_000016.9:g.87502815G>A

Gene: ZCCHC14, zinc finger CCHC-type containing 14(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
ZCCHC14 transcript	NM_015144.2:c.	N/A	Intron Variant
ZCCHC14 transcript variant X1	XM_005255858.3:c.	N/A	Intron Variant
ZCCHC14 transcript variant X4	XM_011522964.2:c.	N/A	Intron Variant
ZCCHC14 transcript variant X3	XM_017023082.1:c.	N/A	Genic Upstream Transcript Variant
ZCCHC14 transcript variant X2	XR_243401.3:n.	N/A	Intron Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.314	A=0.686
1000Genomes	American	Sub	694	G=0.620	A=0.380
1000Genomes	East Asian	Sub	1008	G=0.549	A=0.451
1000Genomes	Europe	Sub	1006	G=0.872	A=0.128
1000Genomes	Global	Study-wide	5008	G=0.628	A=0.372
1000Genomes	South Asian	Sub	978	G=0.890	A=0.110
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.869	A=0.131
The Genome Aggregation Database	African	Sub	8694	G=0.401	A=0.599
The Genome Aggregation Database	American	Sub	836	G=0.610	A=0.390
The Genome Aggregation Database	East Asian	Sub	1616	G=0.555	A=0.445
The Genome Aggregation Database	Europe	Sub	18464	G=0.868	A=0.132
The Genome Aggregation Database	Global	Study-wide	29912	G=0.707	A=0.292
The Genome Aggregation Database	Other	Sub	302	G=0.850	A=0.150
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.640	A=0.359
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.869	A=0.131

PMID	Title	Author	Journal
22377092	ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.	Wang KS	Drug Alcohol Depend

P-Value

SNP ID	p-value	Traits	Study
rs9936994	6.91E-05	nicotine dependence (smoking)	22377092

eQTL of rs9936994 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs9936994 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr16	87468266	87468306	E067	-34509
chr16	87468827	87468877	E067	-33938
chr16	87468933	87470319	E067	-32496
chr16	87470375	87470601	E067	-32214
chr16	87494647	87494702	E067	-8113
chr16	87494728	87494891	E067	-7924
chr16	87494927	87495666	E067	-7149
chr16	87496707	87496808	E067	-6007
chr16	87496885	87496935	E067	-5880
chr16	87497015	87497069	E067	-5746
chr16	87497357	87499382	E067	-3433
chr16	87499503	87499877	E067	-2938
chr16	87499913	87500113	E067	-2702
chr16	87500224	87500472	E067	-2343
chr16	87500504	87500620	E067	-2195
chr16	87503405	87503556	E067	590
chr16	87503940	87504017	E067	1125
chr16	87504028	87504110	E067	1213
chr16	87504114	87504232	E067	1299
chr16	87504294	87504388	E067	1479
chr16	87504855	87505216	E067	2040
chr16	87505233	87505591	E067	2418
chr16	87505701	87505786	E067	2886
chr16	87505965	87506043	E067	3150
chr16	87509312	87509634	E067	6497
chr16	87509648	87509725	E067	6833
chr16	87509735	87509872	E067	6920
chr16	87510929	87511529	E067	8114
chr16	87514546	87514606	E067	11731
chr16	87514649	87514699	E067	11834
chr16	87518629	87518708	E067	15814
chr16	87519327	87519367	E067	16512
chr16	87519424	87519590	E067	16609
chr16	87519645	87519742	E067	16830
chr16	87519790	87519831	E067	16975
chr16	87519959	87520035	E067	17144
chr16	87520047	87520148	E067	17232
chr16	87520334	87520459	E067	17519
chr16	87520489	87520775	E067	17674
chr16	87551964	87552117	E067	49149
chr16	87552137	87552221	E067	49322
chr16	87552290	87552554	E067	49475
chr16	87552600	87552685	E067	49785
chr16	87457706	87457756	E068	-45059
chr16	87458001	87458072	E068	-44743
chr16	87458074	87458218	E068	-44597
chr16	87458225	87458357	E068	-44458
chr16	87458387	87458437	E068	-44378
chr16	87458460	87458511	E068	-44304
chr16	87468827	87468877	E068	-33938
chr16	87468933	87470319	E068	-32496
chr16	87470375	87470601	E068	-32214
chr16	87494927	87495666	E068	-7149
chr16	87497357	87499382	E068	-3433
chr16	87499503	87499877	E068	-2938
chr16	87499913	87500113	E068	-2702
chr16	87502280	87502410	E068	-405
chr16	87502481	87502597	E068	-218
chr16	87502851	87502999	E068	36
chr16	87503405	87503556	E068	590
chr16	87504855	87505216	E068	2040
chr16	87505233	87505591	E068	2418
chr16	87505701	87505786	E068	2886
chr16	87505965	87506043	E068	3150
chr16	87506230	87506290	E068	3415
chr16	87509312	87509634	E068	6497
chr16	87509648	87509725	E068	6833
chr16	87509735	87509872	E068	6920
chr16	87510394	87510476	E068	7579
chr16	87510669	87510752	E068	7854
chr16	87510847	87510902	E068	8032
chr16	87510929	87511529	E068	8114
chr16	87511809	87511880	E068	8994
chr16	87514546	87514606	E068	11731
chr16	87514649	87514699	E068	11834
chr16	87514778	87514822	E068	11963
chr16	87517959	87518365	E068	15144
chr16	87518370	87518589	E068	15555
chr16	87518629	87518708	E068	15814
chr16	87518730	87518848	E068	15915
chr16	87519327	87519367	E068	16512
chr16	87519424	87519590	E068	16609
chr16	87519645	87519742	E068	16830
chr16	87519790	87519831	E068	16975
chr16	87519959	87520035	E068	17144
chr16	87520047	87520148	E068	17232
chr16	87520334	87520459	E068	17519
chr16	87521726	87521803	E068	18911
chr16	87521934	87521997	E068	19119
chr16	87522037	87522097	E068	19222
chr16	87540977	87541773	E068	38162
chr16	87551964	87552117	E068	49149
chr16	87552137	87552221	E068	49322
chr16	87552290	87552554	E068	49475
chr16	87552600	87552685	E068	49785
chr16	87458001	87458072	E069	-44743
chr16	87458074	87458218	E069	-44597
chr16	87458225	87458357	E069	-44458
chr16	87458387	87458437	E069	-44378
chr16	87460495	87460644	E069	-42171
chr16	87460656	87460759	E069	-42056
chr16	87460849	87461000	E069	-41815
chr16	87467380	87467445	E069	-35370
chr16	87468827	87468877	E069	-33938
chr16	87468933	87470319	E069	-32496
chr16	87470375	87470601	E069	-32214
chr16	87497357	87499382	E069	-3433
chr16	87499503	87499877	E069	-2938
chr16	87499913	87500113	E069	-2702
chr16	87500224	87500472	E069	-2343
chr16	87502851	87502999	E069	36
chr16	87503405	87503556	E069	590
chr16	87509312	87509634	E069	6497
chr16	87509648	87509725	E069	6833
chr16	87509735	87509872	E069	6920
chr16	87510929	87511529	E069	8114
chr16	87519424	87519590	E069	16609
chr16	87519645	87519742	E069	16830
chr16	87519790	87519831	E069	16975
chr16	87519959	87520035	E069	17144
chr16	87520047	87520148	E069	17232
chr16	87520334	87520459	E069	17519
chr16	87520489	87520775	E069	17674
chr16	87540385	87540456	E069	37570
chr16	87540482	87540596	E069	37667
chr16	87540739	87540950	E069	37924
chr16	87540977	87541773	E069	38162
chr16	87549470	87549823	E069	46655
chr16	87510847	87510902	E070	8032
chr16	87510929	87511529	E070	8114
chr16	87519959	87520035	E070	17144
chr16	87520047	87520148	E070	17232
chr16	87520334	87520459	E070	17519
chr16	87520489	87520775	E070	17674
chr16	87521934	87521997	E070	19119
chr16	87522426	87522486	E070	19611
chr16	87522612	87522874	E070	19797
chr16	87527621	87527759	E070	24806
chr16	87549243	87549327	E070	46428
chr16	87549470	87549823	E070	46655
chr16	87468266	87468306	E071	-34509
chr16	87468827	87468877	E071	-33938
chr16	87468933	87470319	E071	-32496
chr16	87470375	87470601	E071	-32214
chr16	87471042	87471118	E071	-31697
chr16	87494728	87494891	E071	-7924
chr16	87494927	87495666	E071	-7149
chr16	87497357	87499382	E071	-3433
chr16	87499503	87499877	E071	-2938
chr16	87499913	87500113	E071	-2702
chr16	87500224	87500472	E071	-2343
chr16	87502280	87502410	E071	-405
chr16	87502481	87502597	E071	-218
chr16	87502851	87502999	E071	36
chr16	87503405	87503556	E071	590
chr16	87503940	87504017	E071	1125
chr16	87504028	87504110	E071	1213
chr16	87504114	87504232	E071	1299
chr16	87504294	87504388	E071	1479
chr16	87504657	87504701	E071	1842
chr16	87504855	87505216	E071	2040
chr16	87505233	87505591	E071	2418
chr16	87505701	87505786	E071	2886
chr16	87505965	87506043	E071	3150
chr16	87508425	87508831	E071	5610
chr16	87509312	87509634	E071	6497
chr16	87509648	87509725	E071	6833
chr16	87509735	87509872	E071	6920
chr16	87510394	87510476	E071	7579
chr16	87510669	87510752	E071	7854
chr16	87510847	87510902	E071	8032
chr16	87514546	87514606	E071	11731
chr16	87514649	87514699	E071	11834
chr16	87514778	87514822	E071	11963
chr16	87514909	87514982	E071	12094
chr16	87517959	87518365	E071	15144
chr16	87518370	87518589	E071	15555
chr16	87519424	87519590	E071	16609
chr16	87519645	87519742	E071	16830
chr16	87519790	87519831	E071	16975
chr16	87519959	87520035	E071	17144
chr16	87520047	87520148	E071	17232
chr16	87520334	87520459	E071	17519
chr16	87520489	87520775	E071	17674
chr16	87521726	87521803	E071	18911
chr16	87521934	87521997	E071	19119
chr16	87522037	87522097	E071	19222
chr16	87522269	87522309	E071	19454
chr16	87522426	87522486	E071	19611
chr16	87522612	87522874	E071	19797
chr16	87540977	87541773	E071	38162
chr16	87542047	87542101	E071	39232
chr16	87549470	87549823	E071	46655
chr16	87551964	87552117	E071	49149
chr16	87552137	87552221	E071	49322
chr16	87552290	87552554	E071	49475
chr16	87552600	87552685	E071	49785
chr16	87468266	87468306	E072	-34509
chr16	87468827	87468877	E072	-33938
chr16	87468933	87470319	E072	-32496
chr16	87494647	87494702	E072	-8113
chr16	87494728	87494891	E072	-7924
chr16	87494927	87495666	E072	-7149
chr16	87497357	87499382	E072	-3433
chr16	87499503	87499877	E072	-2938
chr16	87499913	87500113	E072	-2702
chr16	87500224	87500472	E072	-2343
chr16	87500504	87500620	E072	-2195
chr16	87500832	87501102	E072	-1713
chr16	87501125	87501169	E072	-1646
chr16	87502851	87502999	E072	36
chr16	87503405	87503556	E072	590
chr16	87503940	87504017	E072	1125
chr16	87504028	87504110	E072	1213
chr16	87509312	87509634	E072	6497
chr16	87509648	87509725	E072	6833
chr16	87509735	87509872	E072	6920
chr16	87510394	87510476	E072	7579
chr16	87510669	87510752	E072	7854
chr16	87510847	87510902	E072	8032
chr16	87510929	87511529	E072	8114
chr16	87514546	87514606	E072	11731
chr16	87514649	87514699	E072	11834
chr16	87514778	87514822	E072	11963
chr16	87519645	87519742	E072	16830
chr16	87519790	87519831	E072	16975
chr16	87519959	87520035	E072	17144
chr16	87520047	87520148	E072	17232
chr16	87520334	87520459	E072	17519
chr16	87520489	87520775	E072	17674
chr16	87540977	87541773	E072	38162
chr16	87552600	87552685	E072	49785
chr16	87458001	87458072	E073	-44743
chr16	87458074	87458218	E073	-44597
chr16	87458225	87458357	E073	-44458
chr16	87458387	87458437	E073	-44378
chr16	87458460	87458511	E073	-44304
chr16	87458776	87458826	E073	-43989
chr16	87460194	87460331	E073	-42484
chr16	87465154	87466019	E073	-36796
chr16	87466122	87466210	E073	-36605
chr16	87468266	87468306	E073	-34509
chr16	87468827	87468877	E073	-33938
chr16	87468933	87470319	E073	-32496
chr16	87470375	87470601	E073	-32214
chr16	87494647	87494702	E073	-8113
chr16	87494728	87494891	E073	-7924
chr16	87494927	87495666	E073	-7149
chr16	87496707	87496808	E073	-6007
chr16	87496885	87496935	E073	-5880
chr16	87497015	87497069	E073	-5746
chr16	87497357	87499382	E073	-3433
chr16	87499503	87499877	E073	-2938
chr16	87499913	87500113	E073	-2702
chr16	87500224	87500472	E073	-2343
chr16	87500504	87500620	E073	-2195
chr16	87502280	87502410	E073	-405
chr16	87502481	87502597	E073	-218
chr16	87502851	87502999	E073	36
chr16	87503405	87503556	E073	590
chr16	87503940	87504017	E073	1125
chr16	87504028	87504110	E073	1213
chr16	87504114	87504232	E073	1299
chr16	87505233	87505591	E073	2418
chr16	87509312	87509634	E073	6497
chr16	87509648	87509725	E073	6833
chr16	87509735	87509872	E073	6920
chr16	87510394	87510476	E073	7579
chr16	87510669	87510752	E073	7854
chr16	87510847	87510902	E073	8032
chr16	87510929	87511529	E073	8114
chr16	87517844	87517898	E073	15029
chr16	87517959	87518365	E073	15144
chr16	87518370	87518589	E073	15555
chr16	87518629	87518708	E073	15814
chr16	87518730	87518848	E073	15915
chr16	87519327	87519367	E073	16512
chr16	87519424	87519590	E073	16609
chr16	87519645	87519742	E073	16830
chr16	87519790	87519831	E073	16975
chr16	87519959	87520035	E073	17144
chr16	87521726	87521803	E073	18911
chr16	87521934	87521997	E073	19119
chr16	87522037	87522097	E073	19222
chr16	87522269	87522309	E073	19454
chr16	87522426	87522486	E073	19611
chr16	87522612	87522874	E073	19797
chr16	87540385	87540456	E073	37570
chr16	87540482	87540596	E073	37667
chr16	87540739	87540950	E073	37924
chr16	87540977	87541773	E073	38162
chr16	87550101	87550202	E073	47286
chr16	87550805	87551110	E073	47990
chr16	87551158	87551510	E073	48343
chr16	87551593	87551874	E073	48778
chr16	87551964	87552117	E073	49149
chr16	87552137	87552221	E073	49322
chr16	87552290	87552554	E073	49475
chr16	87552600	87552685	E073	49785
chr16	87468827	87468877	E074	-33938
chr16	87468933	87470319	E074	-32496
chr16	87470375	87470601	E074	-32214
chr16	87497357	87499382	E074	-3433
chr16	87499503	87499877	E074	-2938
chr16	87499913	87500113	E074	-2702
chr16	87500224	87500472	E074	-2343
chr16	87500504	87500620	E074	-2195
chr16	87509312	87509634	E074	6497
chr16	87509648	87509725	E074	6833
chr16	87509735	87509872	E074	6920
chr16	87510394	87510476	E074	7579
chr16	87510669	87510752	E074	7854
chr16	87510847	87510902	E074	8032
chr16	87510929	87511529	E074	8114
chr16	87517959	87518365	E074	15144
chr16	87518370	87518589	E074	15555
chr16	87519424	87519590	E074	16609
chr16	87519645	87519742	E074	16830
chr16	87519790	87519831	E074	16975
chr16	87519959	87520035	E074	17144
chr16	87520047	87520148	E074	17232
chr16	87520334	87520459	E074	17519
chr16	87520489	87520775	E074	17674
chr16	87521726	87521803	E074	18911
chr16	87521934	87521997	E074	19119
chr16	87522037	87522097	E074	19222
chr16	87522269	87522309	E074	19454
chr16	87522426	87522486	E074	19611
chr16	87522612	87522874	E074	19797
chr16	87540005	87540316	E074	37190
chr16	87540385	87540456	E074	37570
chr16	87540482	87540596	E074	37667
chr16	87540739	87540950	E074	37924
chr16	87540977	87541773	E074	38162
chr16	87488365	87488415	E081	-14400
chr16	87488467	87488511	E081	-14304
chr16	87488990	87489040	E081	-13775
chr16	87509312	87509634	E081	6497
chr16	87509648	87509725	E081	6833
chr16	87509735	87509872	E081	6920
chr16	87510394	87510476	E081	7579
chr16	87510669	87510752	E081	7854
chr16	87510847	87510902	E081	8032
chr16	87510929	87511529	E081	8114
chr16	87515818	87516128	E081	13003
chr16	87516744	87516784	E081	13929
chr16	87517197	87517475	E081	14382
chr16	87517673	87517723	E081	14858
chr16	87517844	87517898	E081	15029
chr16	87517959	87518365	E081	15144
chr16	87518370	87518589	E081	15555
chr16	87518629	87518708	E081	15814
chr16	87518730	87518848	E081	15915
chr16	87519327	87519367	E081	16512
chr16	87519424	87519590	E081	16609
chr16	87519645	87519742	E081	16830
chr16	87519790	87519831	E081	16975
chr16	87519959	87520035	E081	17144
chr16	87520047	87520148	E081	17232
chr16	87520334	87520459	E081	17519
chr16	87520489	87520775	E081	17674
chr16	87521726	87521803	E081	18911
chr16	87521934	87521997	E081	19119
chr16	87522037	87522097	E081	19222
chr16	87522269	87522309	E081	19454
chr16	87522426	87522486	E081	19611
chr16	87522612	87522874	E081	19797
chr16	87527621	87527759	E081	24806
chr16	87549243	87549327	E081	46428
chr16	87549470	87549823	E081	46655
chr16	87550101	87550202	E081	47286
chr16	87550340	87550467	E081	47525
chr16	87550514	87550697	E081	47699
chr16	87550805	87551110	E081	47990
chr16	87551158	87551510	E081	48343
chr16	87551593	87551874	E081	48778
chr16	87551964	87552117	E081	49149
chr16	87489373	87489868	E082	-12947
chr16	87519645	87519742	E082	16830
chr16	87519790	87519831	E082	16975
chr16	87519959	87520035	E082	17144
chr16	87520047	87520148	E082	17232
chr16	87549470	87549823	E082	46655
chr16	87550101	87550202	E082	47286
chr16	87550340	87550467	E082	47525
chr16	87550514	87550697	E082	47699
chr16	87552137	87552221	E082	49322
chr16	87552290	87552554	E082	49475
chr16	87552600	87552685	E082	49785

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr16	87523945	87524785	E067	21130
chr16	87525319	87525586	E067	22504
chr16	87525676	87525886	E067	22861
chr16	87526297	87527176	E067	23482
chr16	87523945	87524785	E068	21130
chr16	87525319	87525586	E068	22504
chr16	87525676	87525886	E068	22861
chr16	87523945	87524785	E069	21130
chr16	87525319	87525586	E069	22504
chr16	87525676	87525886	E069	22861
chr16	87525972	87526113	E069	23157
chr16	87526115	87526170	E069	23300
chr16	87526171	87526248	E069	23356
chr16	87526297	87527176	E069	23482
chr16	87523945	87524785	E070	21130
chr16	87525319	87525586	E070	22504
chr16	87525676	87525886	E070	22861
chr16	87525972	87526113	E070	23157
chr16	87526115	87526170	E070	23300
chr16	87526171	87526248	E070	23356
chr16	87526297	87527176	E070	23482
chr16	87523945	87524785	E071	21130
chr16	87525319	87525586	E071	22504
chr16	87525676	87525886	E071	22861
chr16	87523945	87524785	E072	21130
chr16	87525319	87525586	E072	22504
chr16	87525676	87525886	E072	22861
chr16	87525972	87526113	E072	23157
chr16	87526115	87526170	E072	23300
chr16	87526171	87526248	E072	23356
chr16	87526297	87527176	E072	23482
chr16	87523945	87524785	E073	21130
chr16	87525319	87525586	E073	22504
chr16	87525676	87525886	E073	22861
chr16	87523945	87524785	E074	21130
chr16	87525319	87525586	E074	22504
chr16	87525676	87525886	E074	22861
chr16	87536008	87536048	E081	33193
chr16	87523945	87524785	E082	21130
chr16	87525319	87525586	E082	22504
chr16	87525676	87525886	E082	22861
chr16	87525972	87526113	E082	23157
chr16	87526115	87526170	E082	23300
chr16	87526171	87526248	E082	23356
chr16	87526297	87527176	E082	23482