DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
ACEGTPEK
Uniprot ID:
Q5VWT5
Source protein:
FYN-binding protein 2
Source gene:
FYB2
Class:
DEG_SCF_SKP2-CKS1_1
Location:
412:419
E3 ligase:
SKP2,CSK1
DEGRON score:
0.9839
ASA_SCORE:
83.925
COIL:
0.816
CONS_SCORE:
0.3957
DSS_SCORE:
0.4174
HELIX:
0.0349
FCONS_SCORE:
1.1808
RIG_SCORE:
0.7314
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FYB2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ACEGTPEK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VWT5
FYN-binding protein 2
DEG_SCF_SKP2-CKS1_1
412:419
ACEGTPEK
SKP2,CSK1
0.9839
More...