DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ACEGTPEK
Uniprot ID:
Q5VWT5
Source protein:
FYN-binding protein 2
Source gene:
FYB2
Class:
DEG_SCF_SKP2-CKS1_1
Location:
412:419
E3 ligase:
SKP2,CSK1
DEGRON score:
0.9839
ASA_SCORE:
83.925
COIL:
0.816
CONS_SCORE:
0.3957
DSS_SCORE:
0.4174
HELIX:
0.0349
FCONS_SCORE:
1.1808
RIG_SCORE:
0.7314
Degron related mutations and impact score
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Drug responses associated with FYB2 mutations
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All proteins holding degron of ACEGTPEK
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
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Q5VWT5
FYN-binding protein 2
DEG_SCF_SKP2-CKS1_1
412:419
ACEGTPEK
SKP2,CSK1
0.9839
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