DegronMD

Uniprot ID: Q9NRY4

Source protein: Rho GTPase-activating protein 35

Source gene: ARHGAP35

Class: DEG_SPOP_SBC_1

Location: 960:964

E3 ligase: SPOP

DEGRON score: 0.998

ASA_SCORE: 65.3

COIL: 0.7778

CONS_SCORE: 0.402

DSS_SCORE: 0.3844

HELIX: 0.1966

FCONS_SCORE: 0.9923

RIG_SCORE: 0.7603

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S962T	TCGA-44-5644	LUAD	TCGA	ACSTT	DEG_SPOP_SBC_1	0.7116
p.S962T	DO25153	LUAD	ICGC	ACSTT	DEG_SPOP_SBC_1	0.7116
p.S962T	SIDM00962	Chronic Myelogenous Leukemia	GDSC	ACSTT	DEG_SPOP_SBC_1	0.7116
p.S962T	SIDM00467	Acute Myeloid Leukemia	GDSC	ACSTT	DEG_SPOP_SBC_1	0.7116
p.S962T	SIDM01001	Breast Carcinoma	GDSC	ACSTT	DEG_SPOP_SBC_1	0.7116
p.E965K	TCGA-AP-A0LM	UCEC	TCGA	ACSTT	DEG_SPOP_SBC_1	0.3056
p.E965K	DO43306	UCEC	ICGC	ACSTT	DEG_SPOP_SBC_1	0.3056
p.N969I	TCGA-CC-A7II	LIHC	TCGA	ACSTT	DEG_SPOP_SBC_1	0.1944
p.N969I	DO52182	LIHC	ICGC	ACSTT	DEG_SPOP_SBC_1	0.1944
p.H952Y	TCGA-D3-A8GM	SKCM	TCGA	ACSTT	DEG_SPOP_SBC_1	0.1111
p.H952Y	DO50288	SKCM	ICGC	ACSTT	DEG_SPOP_SBC_1	0.1111
p.H952N	TCGA-F5-6814	READ	TCGA	ACSTT	DEG_SPOP_SBC_1	0.1111
p.H952N	DO36556	READ	ICGC	ACSTT	DEG_SPOP_SBC_1	0.1111
p.S962N	TCGA-IB-7651	PAAD	TCGA	ACSTT	DEG_SPOP_SBC_1	0.818
p.S962N	DO46657	PAAD	ICGC	ACSTT	DEG_SPOP_SBC_1	0.818
p.P971L	TCGA-W3-A828	SKCM	TCGA	ACSTT	DEG_SPOP_SBC_1	0.1389
p.P971L	DO51273	SKCM	ICGC	ACSTT	DEG_SPOP_SBC_1	0.1389
p.E959D	DO227709	COCA	ICGC	ACSTT	DEG_SPOP_SBC_1	0.3056
p.Y954H	SIDM01259	B-Lymphoblastic Leukemia	GDSC	ACSTT	DEG_SPOP_SBC_1	0.1667
p.Y954H	ACH-001669	Leukemia	CCLE	ACSTT	DEG_SPOP_SBC_1	0.1667
p.Y954H	ACH-002238	Leukemia	CCLE	ACSTT	DEG_SPOP_SBC_1	0.1667
p.Y954H	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	ACSTT	DEG_SPOP_SBC_1	0.1667
p.R972P	SIDM00889	Cervical Carcinoma	GDSC	ACSTT	DEG_SPOP_SBC_1	0.1111
p.M953I	SIDM01229	Neuroblastoma	GDSC	ACSTT	DEG_SPOP_SBC_1	0.1389
p.M953I	ACH-002217	Neuroblastoma	CCLE	ACSTT	DEG_SPOP_SBC_1	0.1389
p.M953I	BE2-M17	autonomic_ganglia	COSMIC	ACSTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRY4	Rho GTPase-activating protein 35	DEG_SPOP_SBC_1	960:964	ACSTT	SPOP	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ACSTT

Degron related mutations and impact score

Drug responses associated with ARHGAP35 mutations

All proteins holding degron of ACSTT