DegronMD - Q9NRY4(ARHGAP35)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1045H	TCGA-19-5956	GBM	TCGA	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation altering degron motif	0.6583
p.P1045H	DO13863	GBM	ICGC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation altering degron motif	0.6583
p.L1059S	TCGA-22-5482	LUSC	TCGA	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation rewiring degron network	0.0833
p.L1059S	DO26457	LUSC	ICGC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation rewiring degron network	0.0833
p.S962T	TCGA-44-5644	LUAD	TCGA	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation altering degron motif	0.7116
p.S962T	DO25153	LUAD	ICGC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation altering degron motif	0.7116
p.S962T	SIDM00962	Chronic Myelogenous Leukemia	GDSC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation altering degron motif	0.7116
p.S962T	SIDM00467	Acute Myeloid Leukemia	GDSC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation altering degron motif	0.7116
p.S962T	SIDM01001	Breast Carcinoma	GDSC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation altering degron motif	0.7116
p.E965K	TCGA-AP-A0LM	UCEC	TCGA	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.3056
p.E965K	DO43306	UCEC	ICGC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.3056
p.N969I	TCGA-CC-A7II	LIHC	TCGA	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1944
p.N969I	DO52182	LIHC	ICGC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1944
p.P1039L	TCGA-D1-A17Q	UCEC	TCGA	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation rewiring degron network	0.1944
p.P1039L	DO41903	UCEC	ICGC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation rewiring degron network	0.1944
p.H952Y	TCGA-D3-A8GM	SKCM	TCGA	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1111
p.H952Y	DO50288	SKCM	ICGC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1111
p.P1039Q	TCGA-EE-A2GK	SKCM	TCGA	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation rewiring degron network	0.1944
p.P1039Q	DO37738	SKCM	ICGC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation rewiring degron network	0.1944
p.S1472P	TCGA-EO-A22R	UCEC	TCGA	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.25
p.S1472P	DO42713	UCEC	ICGC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.25
p.H952N	TCGA-F5-6814	READ	TCGA	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1111
p.H952N	DO36556	READ	ICGC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1111
p.S1472L	TCGA-FI-A2D0	UCEC	TCGA	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.25
p.S1472L	DO43891	UCEC	ICGC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.25
p.S962N	TCGA-IB-7651	PAAD	TCGA	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation altering degron motif	0.818
p.S962N	DO46657	PAAD	ICGC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation altering degron motif	0.818
p.I1051N	TCGA-VQ-A8P2	STAD	TCGA	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation rewiring degron network	0.3056
p.I1051N	DO51761	STAD	ICGC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation rewiring degron network	0.3056
p.P971L	TCGA-W3-A828	SKCM	TCGA	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1389
p.P971L	DO51273	SKCM	ICGC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1389
p.E959D	DO227709	COCA	ICGC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.3056
p.T1468R	DO231140	LAML	ICGC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation altering degron motif	0.6765
p.V1467F	DO228978	LICA	ICGC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation altering degron motif	0.5957
p.V1467F	DO229041	LICA	ICGC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation altering degron motif	0.5957
p.E1050K	DO231862	LINC	ICGC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation altering degron motif	0.7022
p.K1042I	SIDM00458	Acute Myeloid Leukemia	GDSC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation rewiring degron network	0.2778
p.K1042I	ACH-000751	Leukemia	CCLE	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation rewiring degron network	0.2778
p.K1042I	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	1044:1050	Mutation rewiring degron network	0.2778
p.Y954H	SIDM01259	B-Lymphoblastic Leukemia	GDSC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1667
p.Y954H	ACH-001669	Leukemia	CCLE	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1667
p.Y954H	ACH-002238	Leukemia	CCLE	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1667
p.Y954H	GR-ST	haematopoietic and lymphoid tissue	COSMIC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1667
p.V1455M	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.1389
p.V1455M	SIDM00487	Colorectal Carcinoma	GDSC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.1389
p.V1455M	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.1389
p.V1455M	CCK-81	large intestine	COSMIC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.1389
p.R972P	SIDM00889	Cervical Carcinoma	GDSC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1111
p.V1459I	SIDM00487	Colorectal Carcinoma	GDSC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.25
p.V1459I	SIDM00930	Osteosarcoma	GDSC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.25
p.V1459I	CAL-72	bone	COSMIC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.25
p.V1459I	CCK-81	large intestine	COSMIC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.25
p.P1452S	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.0556
p.P1452S	ACH-000865	Esophageal Cancer	CCLE	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.0556
p.P1452S	KYSE-450	oesophagus	COSMIC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.0556
p.M953I	SIDM01229	Neuroblastoma	GDSC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1389
p.M953I	ACH-002217	Neuroblastoma	CCLE	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1389
p.M953I	BE2-M17	autonomic ganglia	COSMIC	ACSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1389
p.P1460L	SIDM01460	Glioma	GDSC	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.2778
p.P1460L	ACH-000592	Brain Cancer	CCLE	LTSTPVTS	DEG_SCF_FBW7_1	1462:1469	Mutation rewiring degron network	0.2778

Kaplan plot for ARHGAP35 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP35

UniProt ID: Q9NRY4

Entrez ID: 2909

Protein name: Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP35 in