DegronMD

Uniprot ID: Q9NRY4

Source protein: Rho GTPase-activating protein 35

Source gene: ARHGAP35

Class: LIG_APCC_ABBAyCdc20_2

Location: 1044:1050

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9727

ASA_SCORE: 96.0857

COIL: 0.8181

CONS_SCORE: 0.3585

DSS_SCORE: 0.5765

HELIX: 0.0389

FCONS_SCORE: 0.895

RIG_SCORE: 0.7196

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1045H	TCGA-19-5956	GBM	TCGA	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.6583
p.P1045H	DO13863	GBM	ICGC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.6583
p.L1059S	TCGA-22-5482	LUSC	TCGA	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.0833
p.L1059S	DO26457	LUSC	ICGC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P1039L	TCGA-D1-A17Q	UCEC	TCGA	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P1039L	DO41903	UCEC	ICGC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P1039Q	TCGA-EE-A2GK	SKCM	TCGA	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P1039Q	DO37738	SKCM	ICGC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.I1051N	TCGA-VQ-A8P2	STAD	TCGA	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.3056
p.I1051N	DO51761	STAD	ICGC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E1050K	DO231862	LINC	ICGC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.7022
p.K1042I	SIDM00458	Acute Myeloid Leukemia	GDSC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K1042I	ACH-000751	Leukemia	CCLE	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K1042I	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	KPPVHFE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRY4	Rho GTPase-activating protein 35	LIG_APCC_ABBAyCdc20_2	1044:1050	KPPVHFE	APC,CDC20,FZR1	0.9727	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons