DegronMD

Uniprot ID: Q9NRY4

Source protein: Rho GTPase-activating protein 35

Source gene: ARHGAP35

Class: DEG_SCF_FBW7_1

Location: 1462:1469

E3 ligase: FBXW7

DEGRON score: 0.9825

ASA_SCORE: 93.8125

COIL: 0.9615

CONS_SCORE: 0.2497

DSS_SCORE: 0.6819

HELIX: 0.0146

FCONS_SCORE: 1.1204

RIG_SCORE: 0.5924

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1472P	TCGA-EO-A22R	UCEC	TCGA	LTSTPVTS	DEG_SCF_FBW7_1	0.25
p.S1472P	DO42713	UCEC	ICGC	LTSTPVTS	DEG_SCF_FBW7_1	0.25
p.S1472L	TCGA-FI-A2D0	UCEC	TCGA	LTSTPVTS	DEG_SCF_FBW7_1	0.25
p.S1472L	DO43891	UCEC	ICGC	LTSTPVTS	DEG_SCF_FBW7_1	0.25
p.T1468R	DO231140	LAML	ICGC	LTSTPVTS	DEG_SCF_FBW7_1	0.6765
p.V1467F	DO228978	LICA	ICGC	LTSTPVTS	DEG_SCF_FBW7_1	0.5957
p.V1467F	DO229041	LICA	ICGC	LTSTPVTS	DEG_SCF_FBW7_1	0.5957
p.V1455M	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LTSTPVTS	DEG_SCF_FBW7_1	0.1389
p.V1455M	SIDM00487	Colorectal Carcinoma	GDSC	LTSTPVTS	DEG_SCF_FBW7_1	0.1389
p.V1455M	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LTSTPVTS	DEG_SCF_FBW7_1	0.1389
p.V1455M	CCK-81	large_intestine	COSMIC	LTSTPVTS	DEG_SCF_FBW7_1	0.1389
p.V1459I	SIDM00487	Colorectal Carcinoma	GDSC	LTSTPVTS	DEG_SCF_FBW7_1	0.25
p.V1459I	SIDM00930	Osteosarcoma	GDSC	LTSTPVTS	DEG_SCF_FBW7_1	0.25
p.V1459I	CAL-72	bone	COSMIC	LTSTPVTS	DEG_SCF_FBW7_1	0.25
p.V1459I	CCK-81	large_intestine	COSMIC	LTSTPVTS	DEG_SCF_FBW7_1	0.25
p.P1452S	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	LTSTPVTS	DEG_SCF_FBW7_1	0.0556
p.P1452S	ACH-000865	Esophageal Cancer	CCLE	LTSTPVTS	DEG_SCF_FBW7_1	0.0556
p.P1452S	KYSE-450	oesophagus	COSMIC	LTSTPVTS	DEG_SCF_FBW7_1	0.0556
p.P1460L	SIDM01460	Glioma	GDSC	LTSTPVTS	DEG_SCF_FBW7_1	0.2778
p.P1460L	ACH-000592	Brain Cancer	CCLE	LTSTPVTS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRY4	Rho GTPase-activating protein 35	DEG_SCF_FBW7_1	1462:1469	LTSTPVTS	FBXW7	0.9825	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons