DegronMD

Uniprot ID: Q9NZA1

Source protein: Chloride intracellular channel protein 5

Source gene: CLIC5

Class: DEG_SPOP_SBC_1

Location: 148:152

E3 ligase: SPOP

DEGRON score: 0.9795

ASA_SCORE: 78.06

COIL: 0.7716

CONS_SCORE: 0.2613

DSS_SCORE: 0.281

HELIX: 0.1318

FCONS_SCORE: 1.0479

RIG_SCORE: 0.7154

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S140R	TCGA-AC-A3W5	BRCA	TCGA	AFSTT	DEG_SPOP_SBC_1	0.1111
p.S140R	DO49024	BRCA	ICGC	AFSTT	DEG_SPOP_SBC_1	0.1111
p.E161K	DO234463	ESAD	ICGC	AFSTT	DEG_SPOP_SBC_1	0.0833
p.S140I	DO222549	ESCA	ICGC	AFSTT	DEG_SPOP_SBC_1	0.1111
p.I143V	DO233864	GACA	ICGC	AFSTT	DEG_SPOP_SBC_1	0.1944
p.P155R	DO11902	GBM	ICGC	AFSTT	DEG_SPOP_SBC_1	0.25
p.T151I	DO228743	LICA	ICGC	AFSTT	DEG_SPOP_SBC_1	0.7078
p.T151I	ACH-002509	Skin Cancer	CCLE	AFSTT	DEG_SPOP_SBC_1	0.7078
p.P157L	DO228919	LICA	ICGC	AFSTT	DEG_SPOP_SBC_1	0.6389
p.D161E	DO229034	LICA	ICGC	AFSTT	DEG_SPOP_SBC_1	0.0833
p.T142N	DO229041	LICA	ICGC	AFSTT	DEG_SPOP_SBC_1	0.1667
p.T142S	DO45442	LUSC	ICGC	AFSTT	DEG_SPOP_SBC_1	0.1667
p.N153K	DO46779	PAEN	ICGC	AFSTT	DEG_SPOP_SBC_1	0.3056
p.E138K	DO219482	SKCM	ICGC	AFSTT	DEG_SPOP_SBC_1	0.0556
p.K153T	SIDM01041	Esophageal Carcinoma	GDSC	AFSTT	DEG_SPOP_SBC_1	0.3056
p.K153T	SIDM00882	Breast Carcinoma	GDSC	AFSTT	DEG_SPOP_SBC_1	0.3056
p.K153T	ACH-001500	Esophageal Cancer	CCLE	AFSTT	DEG_SPOP_SBC_1	0.3056
p.K153T	FLO-1	oesophagus	COSMIC	AFSTT	DEG_SPOP_SBC_1	0.3056
p.K153T	HCC1419	breast	COSMIC	AFSTT	DEG_SPOP_SBC_1	0.3056
p.S150C	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	AFSTT	DEG_SPOP_SBC_1	0.7541
p.S150C	H513	pleura	COSMIC	AFSTT	DEG_SPOP_SBC_1	0.7541
p.K143E	KYSE-410	oesophagus	COSMIC	AFSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZA1	Chloride intracellular channel protein 5	DEG_SPOP_SBC_1	148:152	AFSTT	SPOP	0.9795	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons