DegronMD - Q9NZA1(CLIC5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P314R	TCGA-06-2561	GBM	TCGA	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation altering degron motif	0.7512
p.T301S	TCGA-96-A4JK	LUSC	TCGA	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation rewiring degron network	0.0556
p.S140R	TCGA-AC-A3W5	BRCA	TCGA	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.S140R	DO49024	BRCA	ICGC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.A321T	TCGA-MQ-A6BL	MESO	TCGA	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation rewiring degron network	0.2222
p.E161K	DO234463	ESAD	ICGC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.S140I	DO222549	ESCA	ICGC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.I143V	DO233864	GACA	ICGC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1944
p.P155R	DO11902	GBM	ICGC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.25
p.T151I	DO228743	LICA	ICGC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7078
p.T151I	ACH-002509	Skin Cancer	CCLE	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7078
p.P157L	DO228919	LICA	ICGC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation blocking phosphorylation signal	0.6389
p.D161E	DO229034	LICA	ICGC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.T142N	DO229041	LICA	ICGC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1667
p.T142S	DO45442	LUSC	ICGC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1667
p.N153K	DO46779	PAEN	ICGC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.E138K	DO219482	SKCM	ICGC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0556
p.T323S	SIDM00232	Kidney Carcinoma	GDSC	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation rewiring degron network	0.1667
p.T323S	SIDM00075	Non-Cancerous	GDSC	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation rewiring degron network	0.1667
p.T323S	SIDM00589	Oral Cavity Carcinoma	GDSC	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation rewiring degron network	0.1667
p.T323S	NCC021	kidney	COSMIC	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation rewiring degron network	0.1667
p.T323S	HSC-3	upper aerodigestive tract	COSMIC	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation rewiring degron network	0.1667
p.E318D	SIDM00915	Small Cell Lung Carcinoma	GDSC	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation rewiring degron network	0.3056
p.E318D	SIDM01107	Melanoma	GDSC	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation rewiring degron network	0.3056
p.E318D	SIDM01759	Hodgkin's Lymphoma	GDSC	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation rewiring degron network	0.3056
p.K302E	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation substituting flanking lysine	0.1944
p.K302E	KYSE-410	oesophagus	COSMIC	LNTPLPE	DEG_SCF_FBW7_2	311:317	Mutation substituting flanking lysine	0.1944
p.K153T	SIDM01041	Esophageal Carcinoma	GDSC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.K153T	SIDM00882	Breast Carcinoma	GDSC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.K153T	ACH-001500	Esophageal Cancer	CCLE	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.K153T	FLO-1	oesophagus	COSMIC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.K153T	HCC1419	breast	COSMIC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.S150C	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7541
p.S150C	H513	pleura	COSMIC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7541
p.K143E	KYSE-410	oesophagus	COSMIC	AFSTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1944

Kaplan plot for CLIC5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLIC5

UniProt ID: Q9NZA1

Entrez ID: 53405

Protein name: Chloride intracellular channel protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLIC5 in