DegronMD

Uniprot ID: Q9NZA1

Source protein: Chloride intracellular channel protein 5

Source gene: CLIC5

Class: DEG_SCF_FBW7_2

Location: 311:317

E3 ligase: FBXW7

DEGRON score: 0.8775

ASA_SCORE: 61.7571

COIL: 0.6736

CONS_SCORE: 0.4014

DSS_SCORE: 0.3788

HELIX: 0.3054

FCONS_SCORE: 1.0414

RIG_SCORE: 0.7524

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P314R	TCGA-06-2561	GBM	TCGA	LNTPLPE	DEG_SCF_FBW7_2	0.7512
p.T301S	TCGA-96-A4JK	LUSC	TCGA	LNTPLPE	DEG_SCF_FBW7_2	0.0556
p.A321T	TCGA-MQ-A6BL	MESO	TCGA	LNTPLPE	DEG_SCF_FBW7_2	0.2222
p.T323S	SIDM00232	Kidney Carcinoma	GDSC	LNTPLPE	DEG_SCF_FBW7_2	0.1667
p.T323S	SIDM00075	Non-Cancerous	GDSC	LNTPLPE	DEG_SCF_FBW7_2	0.1667
p.T323S	SIDM00589	Oral Cavity Carcinoma	GDSC	LNTPLPE	DEG_SCF_FBW7_2	0.1667
p.T323S	NCC021	kidney	COSMIC	LNTPLPE	DEG_SCF_FBW7_2	0.1667
p.T323S	HSC-3	upper_aerodigestive_tract	COSMIC	LNTPLPE	DEG_SCF_FBW7_2	0.1667
p.E318D	SIDM00915	Small Cell Lung Carcinoma	GDSC	LNTPLPE	DEG_SCF_FBW7_2	0.3056
p.E318D	SIDM01107	Melanoma	GDSC	LNTPLPE	DEG_SCF_FBW7_2	0.3056
p.E318D	SIDM01759	Hodgkin's Lymphoma	GDSC	LNTPLPE	DEG_SCF_FBW7_2	0.3056
p.K302E	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	LNTPLPE	DEG_SCF_FBW7_2	0.1944
p.K302E	KYSE-410	oesophagus	COSMIC	LNTPLPE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZA1	Chloride intracellular channel protein 5	DEG_SCF_FBW7_2	311:317	LNTPLPE	FBXW7	0.8775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons