DegronMD

Uniprot ID: P23471

Source protein: Receptor-type tyrosine-protein phosphatase zeta

Source gene: PTPRZ1

Class: DEG_SPOP_SBC_1

Location: 1104:1108

E3 ligase: SPOP

DEGRON score: 0.8241

ASA_SCORE: 70.24

COIL: 0.6556

CONS_SCORE: 0.5409

DSS_SCORE: 0.4223

HELIX: 0.035

FCONS_SCORE: 1.0135

RIG_SCORE: 0.7355

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1115S	TCGA-12-0691	GBM	TCGA	AHTTT	DEG_SPOP_SBC_1	0.1389
p.I1115S	DO11298	GBM	ICGC	AHTTT	DEG_SPOP_SBC_1	0.1389
p.V1118D	TCGA-12-0691	GBM	TCGA	AHTTT	DEG_SPOP_SBC_1	0.0556
p.V1118D	DO11298	GBM	ICGC	AHTTT	DEG_SPOP_SBC_1	0.0556
p.V1110A	TCGA-AX-A2HC	UCEC	TCGA	AHTTT	DEG_SPOP_SBC_1	0.2778
p.V1110A	DO41572	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	0.2778
p.F1099L	TCGA-D1-A17Q	UCEC	TCGA	AHTTT	DEG_SPOP_SBC_1	0.1944
p.F1099L	DO41903	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	0.1944
p.S1102F	TCGA-EO-A22U	UCEC	TCGA	AHTTT	DEG_SPOP_SBC_1	0.2778
p.S1102F	DO43755	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	0.2778
p.H1105D	TCGA-KQ-A41R	BLCA	TCGA	AHTTT	DEG_SPOP_SBC_1	0.6577
p.H1105D	DO223592	BLCA	ICGC	AHTTT	DEG_SPOP_SBC_1	0.6577
p.E1112K	DO502	BLCA	ICGC	AHTTT	DEG_SPOP_SBC_1	0.2222
p.K1109R	DO225056	BRCA	ICGC	AHTTT	DEG_SPOP_SBC_1	0.3056
p.R1105I	DO8898	COAD	ICGC	AHTTT	DEG_SPOP_SBC_1	0.8102
p.R1105I	DO43202	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	0.8102
p.R1105I	DO42793	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	0.8102
p.R1105I	DO41379	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	0.8102
p.V1110G	DO233688	GACA	ICGC	AHTTT	DEG_SPOP_SBC_1	0.2778
p.K1096N	DO229015	LICA	ICGC	AHTTT	DEG_SPOP_SBC_1	0.2222
p.E1113G	DO22857	LIHC	ICGC	AHTTT	DEG_SPOP_SBC_1	0.1944
p.R1102S	DO26854	LUSC	ICGC	AHTTT	DEG_SPOP_SBC_1	0.2778
p.R1102C	DO229502	SKCA	ICGC	AHTTT	DEG_SPOP_SBC_1	0.2778
p.R1102C	ACH-000045	Leukemia	CCLE	AHTTT	DEG_SPOP_SBC_1	0.2778
p.Q1114H	DO41999	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	0.1667
p.D1112E	SIDM01494	Glioblastoma	GDSC	AHTTT	DEG_SPOP_SBC_1	0.2222
p.H1113Y	SIDM01494	Glioblastoma	GDSC	AHTTT	DEG_SPOP_SBC_1	0.1944
p.H1100Q	ACH-000718	Lung Cancer	CCLE	AHTTT	DEG_SPOP_SBC_1	0.2222
p.H1100Q	NCI-H2291	lung	COSMIC	AHTTT	DEG_SPOP_SBC_1	0.2222
p.F1097C	ACH-000846	Head and Neck Cancer	CCLE	AHTTT	DEG_SPOP_SBC_1	0.1389
p.F1097C	FADU	upper_aerodigestive_tract	COSMIC	AHTTT	DEG_SPOP_SBC_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AHTTT

Degron related mutations and impact score

Drug responses associated with PTPRZ1 mutations

All proteins holding degron of AHTTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23471	Receptor-type tyrosine-protein phosphatase zeta	DEG_SPOP_SBC_1	1104:1108	AHTTT	SPOP	0.8241	More...