DegronMD - P23471(PTPRZ1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H968Q	TCGA-05-5425	LUAD	TCGA	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.1111
p.H968Q	DO26270	LUAD	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.1111
p.I1115S	TCGA-12-0691	GBM	TCGA	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.I1115S	DO11298	GBM	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.V1118D	TCGA-12-0691	GBM	TCGA	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.0556
p.V1118D	DO11298	GBM	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.0556
p.P970T	TCGA-17-Z056	LUAD	TCGA	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.1667
p.A885V	TCGA-23-1121	OV	TCGA	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.A885V	TCGA-DU-7299	LGG	TCGA	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.A885V	DO22342	LGG	ICGC	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.A885V	DO28731	OV	ICGC	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.D411Y	TCGA-67-3771	LUAD	TCGA	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation rewiring degron network	0.2222
p.D411Y	DO25797	LUAD	ICGC	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation rewiring degron network	0.2222
p.G893C	TCGA-6A-AB49	LUSC	TCGA	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.0556
p.G893C	DO52020	LUSC	ICGC	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.0556
p.S1380Y	TCGA-A5-A0G2	UCEC	TCGA	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation altering degron motif	0.6009
p.S1380Y	DO41235	UCEC	ICGC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation altering degron motif	0.6009
p.A787S	TCGA-AA-3956	COAD	TCGA	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.6477
p.A787S	DO9700	COAD	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.6477
p.I1319M	TCGA-AA-3977	COAD	TCGA	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.3056
p.I1319M	DO8730	COAD	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.3056
p.S974Y	TCGA-AJ-A3EL	UCEC	TCGA	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.2778
p.S974Y	TCGA-AP-A056	UCEC	TCGA	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.2778
p.S974Y	DO41542	UCEC	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.2778
p.S974Y	DO43971	UCEC	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.2778
p.P1305H	TCGA-AP-A059	UCEC	TCGA	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.1667
p.P1305H	DO41361	UCEC	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.1667
p.T797M	TCGA-AX-A1C9	UCEC	TCGA	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0833
p.T797M	DO43098	UCEC	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0833
p.V1110A	TCGA-AX-A2HC	UCEC	TCGA	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.2778
p.V1110A	DO41572	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.2778
p.K973T	TCGA-BR-8297	STAD	TCGA	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation substituting flanking lysine	0.3611
p.K973T	TCGA-D7-6522	STAD	TCGA	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation substituting flanking lysine	0.3611
p.K973T	DO38555	STAD	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation substituting flanking lysine	0.3611
p.K973T	DO38384	STAD	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation substituting flanking lysine	0.3611
p.K973T	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation substituting flanking lysine	0.3611
p.K973T	ACH-000510	Lung Cancer	CCLE	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation substituting flanking lysine	0.3611
p.K973T	NCI-H1299	lung	COSMIC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation substituting flanking lysine	0.3611
p.K1275T	TCGA-BS-A0UF	UCEC	TCGA	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.3056
p.K1275T	DO41488	UCEC	ICGC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.3056
p.S877Y	TCGA-BS-A0UV	UCEC	TCGA	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.S877Y	DO42793	UCEC	ICGC	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.F1312L	TCGA-CC-A7IH	LIHC	TCGA	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.587
p.F1312L	DO52181	LIHC	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.587
p.G1385C	TCGA-CC-A9FW	LIHC	TCGA	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.3056
p.G1385C	DO219557	LIHC	ICGC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.3056
p.D791V	TCGA-CM-6678	COAD	TCGA	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.25
p.D791V	DO10220	COAD	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.25
p.F1099L	TCGA-D1-A17Q	UCEC	TCGA	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1944
p.F1099L	DO41903	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1944
p.D411N	TCGA-D9-A4Z3	SKCM	TCGA	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation rewiring degron network	0.2222
p.D411N	DO47555	SKCM	ICGC	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation rewiring degron network	0.2222
p.E1267V	TCGA-DD-AACX	LIHC	TCGA	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.0833
p.E1267V	DO52215	LIHC	ICGC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.0833
p.I969L	TCGA-DK-A6B2	BLCA	TCGA	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.1389
p.I969L	DO48543	BLCA	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.1389
p.V1316F	TCGA-EE-A2MF	SKCM	TCGA	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.5957
p.V1316F	DO51249	SKCM	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.5957
p.S1102F	TCGA-EO-A22U	UCEC	TCGA	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.2778
p.S1102F	DO43755	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.2778
p.I780L	TCGA-EO-A3B0	UCEC	TCGA	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.I780L	DO219773	UCEC	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.L417I	TCGA-EY-A1GI	UCEC	TCGA	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation altering degron motif	0.6063
p.L417I	DO41211	UCEC	ICGC	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation altering degron motif	0.6063
p.S1279F	TCGA-FR-A3YN	SKCM	TCGA	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation altering degron motif	0.7982
p.S1279F	DO38111	SKCM	ICGC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation altering degron motif	0.7982
p.H1105D	TCGA-KQ-A41R	BLCA	TCGA	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation altering degron motif	0.6577
p.H1105D	DO223592	BLCA	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation altering degron motif	0.6577
p.V1374A	TCGA-L9-A50W	LUAD	TCGA	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.1944
p.V1374A	DO49872	LUAD	ICGC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.1944
p.P1306Q	TCGA-MP-A4T7	LUAD	TCGA	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.1944
p.P1306Q	DO45370	LUAD	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.1944
p.P773H	TCGA-R5-A7ZI	STAD	TCGA	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.1111
p.P773H	DO222342	STAD	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.1111
p.S1386F	TCGA-YG-AA3P	SKCM	TCGA	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.2778
p.S1386F	DO51300	SKCM	ICGC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.2778
p.H884L	DO48451	BLCA	ICGC	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.3056
p.E1112K	DO502	BLCA	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.2222
p.K1109R	DO225056	BRCA	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.3056
p.L1323V	DO224904	BRCA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.1944
p.S1293C	DO4080	BRCA	ICGC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.1389
p.E1287D	DO8184	COAD	ICGC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.3056
p.L1393M	DO7801	COAD	ICGC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.0833
p.R1105I	DO8898	COAD	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation altering degron motif	0.8102
p.R1105I	DO43202	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation altering degron motif	0.8102
p.R1105I	DO42793	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation altering degron motif	0.8102
p.R1105I	DO41379	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation altering degron motif	0.8102
p.V1316A	DO230347	COCA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.5825
p.D1384N	DO229016	COCA	ICGC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation altering degron motif	0.6932
p.D1384N	DO228947	LICA	ICGC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation altering degron motif	0.6932
p.D1384N	DO230522	LUSC	ICGC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation altering degron motif	0.6932
p.D977Y	DO228709	EOPC	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation altering degron motif	0.7325
p.I1369K	DO50330	ESAD	ICGC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.0556
p.T1390P	DO234233	ESAD	ICGC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.1667
p.C1321R	DO48203	ESCA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.25
p.C1321R	DO22237	LGG	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.25
p.V1110G	DO233688	GACA	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.2778
p.E981Q	DO52083	HNSC	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation altering degron motif	0.6744
p.K969I	DO20909	KIRP	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.1389
p.V782L	DO228986	LICA	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.6765
p.D416Y	DO229018	LICA	ICGC	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation altering degron motif	0.6214
p.K1096N	DO229015	LICA	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation substituting flanking lysine	0.2222
p.W1268C	DO229026	LICA	ICGC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation substituting flanking lysine	0.2222
p.W1268C	DO229034	LICA	ICGC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation substituting flanking lysine	0.2222
p.V406F	DO229031	LICA	ICGC	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation rewiring degron network	0.0833
p.A796S	DO229009	LICA	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.1111
p.E1113G	DO22857	LIHC	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1944
p.V784M	DO45253	LIRI	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.7208
p.P1322H	DO24110	LUAD	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.2222
p.D977V	DO24140	LUAD	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation altering degron motif	0.7785
p.R1102S	DO26854	LUSC	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.2778
p.L1284R	DO52679	MALY	ICGC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation altering degron motif	0.8428
p.AH1303AY	DO220911	MELA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0
p.H1304Y	DO220911	MELA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.1389
p.E1273K	DO222557	MELA	ICGC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.25
p.P1306S	DO222708	MELA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.1944
p.Q1375K	DO233299	NACA	ICGC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.2222
p.D1311N	DO30260	OV	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.6932
p.L771V	DO46657	PAAD	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0556
p.V1311L	DO35424	PACA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.5654
p.Q985H	DO232224	PBCA	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.25
p.E891K	DO218863	SKCA	ICGC	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1111
p.R1102C	DO229502	SKCA	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.2778
p.R1102C	ACH-000045	Leukemia	CCLE	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.2778
p.P1325Q	DO37770	SKCM	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.1389
p.K775T	DO50291	SKCM	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.1667
p.R968I	DO38855	STAD	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.1111
p.S979I	DO38507	STAD	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation altering degron motif	0.7341
p.F789C	DO38599	STAD	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.E1315D	DO51763	STAD	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.6758
p.L1292V	DO51740	STAD	ICGC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.1667
p.P1327L	DO47877	STAD	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.0833
p.N1392D	DO229232	THCA	ICGC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.1111
p.L781F	DO41758	UCEC	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.6981
p.D1302Y	DO41572	UCEC	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.0833
p.Q1114H	DO41999	UCEC	ICGC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1667
p.V1316G	DO42568	UCEC	ICGC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.6421
p.F985V	DO41488	UCEC	ICGC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.25
p.H884R	SIDM00313	Hodgkin's Lymphoma	GDSC	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.3056
p.S789I	SIDM00935	Other Solid Cancers	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.S789I	ACH-002091	Skin Cancer	CCLE	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.S789I	CAL-39	vulva	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.L1273F	SIDM01184	Bladder Carcinoma	GDSC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.25
p.L1273F	SIDM00976	Melanoma	GDSC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.25
p.V771A	SIDM00845	Burkitt's Lymphoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0556
p.V771A	SIDM00461	Acute Myeloid Leukemia	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0556
p.V771A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0556
p.V771A	SIDM01519	Head and Neck Carcinoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0556
p.V771A	Daudi	haematopoietic and lymphoid tissue	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0556
p.V771A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0556
p.I780T	SIDM00845	Burkitt's Lymphoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.I780T	SIDM00461	Acute Myeloid Leukemia	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.I780T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.I780T	SIDM01519	Head and Neck Carcinoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.I780T	Daudi	haematopoietic and lymphoid tissue	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.L990V	SIDM00781	Colorectal Carcinoma	GDSC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.1111
p.L990V	SIDM00780	Colorectal Carcinoma	GDSC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.1111
p.L990V	SNU-C2B	large intestine	COSMIC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.1111
p.D407N	SIDM00789	Colorectal Carcinoma	GDSC	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation rewiring degron network	0.1111
p.D407N	ACH-000997	Colon/Colorectal Cancer	CCLE	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation rewiring degron network	0.1111
p.D407N	ACH-001061	Colon/Colorectal Cancer	CCLE	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation rewiring degron network	0.1111
p.D407N	HCT-15	large intestine	COSMIC	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation rewiring degron network	0.1111
p.P785H	SIDM00660	Colorectal Carcinoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.7694
p.P785H	ACH-000985	Colon/Colorectal Cancer	CCLE	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.7694
p.P785H	LS-411N	large intestine	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.7694
p.Q779E	SIDM00631	Breast Carcinoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.2778
p.Q779E	ACH-001358	Breast Cancer	CCLE	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.2778
p.Q779E	MDA-MB-330	breast	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.2778
p.P1315H	SIDM00782	Colorectal Carcinoma	GDSC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.7694
p.P1315H	ACH-000381	Colon/Colorectal Cancer	CCLE	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.7694
p.P1315H	T84	large intestine	COSMIC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.7694
p.H1280Q	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation altering degron motif	0.647
p.H1280Q	H513	pleura	COSMIC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation altering degron motif	0.647
p.V771I	SIDM01088	Endometrial Carcinoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0556
p.V771I	ACH-000965	Endometrial/Uterine Cancer	CCLE	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0556
p.V771I	RL95-2	endometrium	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.0556
p.H1373L	SIDM00929	Chondrosarcoma	GDSC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.1667
p.S872N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1389
p.S872N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1389
p.L1317I	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.6063
p.L1317I	ACH-000852	Lung Cancer	CCLE	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.6063
p.L1317I	NCI-H1435	lung	COSMIC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.6063
p.A1313S	SIDM00056	Thyroid Gland Carcinoma	GDSC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.6477
p.A1313S	ACH-002148	Thyroid Cancer	CCLE	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.6477
p.A1313S	K5	thyroid	COSMIC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation altering degron motif	0.6477
p.P409S	SIDM00641	Burkitt's Lymphoma	GDSC	LDLFPE	LIG_APCC_ABBA_1	415:420	Mutation rewiring degron network	0.1667
p.Y1269F	SIDM01608	Endometrial Carcinoma	GDSC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.1389
p.N1289S	SIDM01608	Endometrial Carcinoma	GDSC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.25
p.D1112E	SIDM01494	Glioblastoma	GDSC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.2222
p.H1113Y	SIDM01494	Glioblastoma	GDSC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1944
p.A786D	SIDM01520	Oral Cavity Carcinoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.6682
p.F1394L	SIDM01588	Endometrial Carcinoma	GDSC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.0556
p.L1284V	ACH-000308	Ovarian Cancer	CCLE	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation altering degron motif	0.6765
p.L1284V	EFO-21	ovary	COSMIC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation altering degron motif	0.6765
p.D1383V	ACH-000536	Breast Cancer	CCLE	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation altering degron motif	0.7785
p.D1383V	BT-20	breast	COSMIC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation altering degron motif	0.7785
p.H1100Q	ACH-000718	Lung Cancer	CCLE	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.2222
p.H1100Q	NCI-H2291	lung	COSMIC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.2222
p.F1097C	ACH-000846	Head and Neck Cancer	CCLE	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.F1097C	FADU	upper aerodigestive tract	COSMIC	AHTTT	DEG_SPOP_SBC_1	1104:1108	Mutation rewiring degron network	0.1389
p.D977N	ACH-000912	Lung Cancer	CCLE	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation altering degron motif	0.6932
p.D977N	ACH-000956	Prostate Cancer	CCLE	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation altering degron motif	0.6932
p.Q1386H	ACH-000962	Ovarian Cancer	CCLE	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.2778
p.Q1386H	ACH-001145	Ovarian Cancer	CCLE	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.2778
p.Q1386H	OC-314	ovary	COSMIC	VSPHRD	LIG_APCC_ABBA_1	1379:1384	Mutation rewiring degron network	0.2778
p.A875T	ACH-000985	Colon/Colorectal Cancer	CCLE	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2222
p.A875T	LS-411N	large intestine	COSMIC	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2222
p.R888Q	ACH-000986	Colon/Colorectal Cancer	CCLE	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1944
p.R888Q	HT-115	large intestine	COSMIC	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1944
p.N1276H	ACH-000993	Endometrial/Uterine Cancer	CCLE	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation altering degron motif	0.7423
p.N891D	ACH-000996	Endometrial/Uterine Cancer	CCLE	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1111
p.P1269Q	ACH-001021	Liver Cancer	CCLE	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.1389
p.P1269Q	C3A	liver	COSMIC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.1389
p.E1306Q	ACH-001619	Gallbladder Cancer	CCLE	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.1944
p.E1306Q	ACH-002185	Pancreatic Cancer	CCLE	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.1944
p.E1306Q	PL18	pancreas	COSMIC	VFATPVLS	DEG_SCF_FBW7_1	1311:1318	Mutation rewiring degron network	0.1944
p.E980V	ACH-002167	Kidney Cancer	CCLE	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation altering degron motif	0.7693
p.E980V	NCC010	kidney	COSMIC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation altering degron motif	0.7693
p.I783T	WM35	skin	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation altering degron motif	0.7078
p.V1266A	LNCaP-Clone-FGC	prostate	COSMIC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation rewiring degron network	0.0556
p.P780S	Sarc9371	bone	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	781:788	Mutation rewiring degron network	0.3056
p.K1281T	MIA-PaCa-2	pancreas	COSMIC	SESSHQVVPSL	DEG_COP1_1	1276:1286	Mutation altering degron motif	0.7306
p.K886E	LNCaP-Clone-FGC	prostate	COSMIC	VLSTT	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.25
p.Q972R	A204	soft tissue	COSMIC	LITPTAS	DEG_SCF_FBW7_1	976:982	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPRZ1

UniProt ID: P23471

Entrez ID: 5803

Protein name: Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PTPRZ1 in