DegronMD

Uniprot ID: P23471

Source protein: Receptor-type tyrosine-protein phosphatase zeta

Source gene: PTPRZ1

Class: LIG_APCC_ABBA_1

Location: 415:420

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9524

ASA_SCORE: 76.5333

COIL: 0.6733

CONS_SCORE: 0.6091

DSS_SCORE: 0.4945

HELIX: 0.1748

FCONS_SCORE: 1.0835

RIG_SCORE: 0.8564

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D411Y	TCGA-67-3771	LUAD	TCGA	LDLFPE	LIG_APCC_ABBA_1	0.2222
p.D411Y	DO25797	LUAD	ICGC	LDLFPE	LIG_APCC_ABBA_1	0.2222
p.D411N	TCGA-D9-A4Z3	SKCM	TCGA	LDLFPE	LIG_APCC_ABBA_1	0.2222
p.D411N	DO47555	SKCM	ICGC	LDLFPE	LIG_APCC_ABBA_1	0.2222
p.L417I	TCGA-EY-A1GI	UCEC	TCGA	LDLFPE	LIG_APCC_ABBA_1	0.6063
p.L417I	DO41211	UCEC	ICGC	LDLFPE	LIG_APCC_ABBA_1	0.6063
p.D416Y	DO229018	LICA	ICGC	LDLFPE	LIG_APCC_ABBA_1	0.6214
p.V406F	DO229031	LICA	ICGC	LDLFPE	LIG_APCC_ABBA_1	0.0833
p.D407N	SIDM00789	Colorectal Carcinoma	GDSC	LDLFPE	LIG_APCC_ABBA_1	0.1111
p.D407N	ACH-000997	Colon/Colorectal Cancer	CCLE	LDLFPE	LIG_APCC_ABBA_1	0.1111
p.D407N	ACH-001061	Colon/Colorectal Cancer	CCLE	LDLFPE	LIG_APCC_ABBA_1	0.1111
p.D407N	HCT-15	large_intestine	COSMIC	LDLFPE	LIG_APCC_ABBA_1	0.1111
p.P409S	SIDM00641	Burkitt's Lymphoma	GDSC	LDLFPE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23471	Receptor-type tyrosine-protein phosphatase zeta	LIG_APCC_ABBA_1	415:420	LDLFPE	APC,CDC20,FZR1	0.9524	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons