DegronMD

Uniprot ID: P23471

Source protein: Receptor-type tyrosine-protein phosphatase zeta

Source gene: PTPRZ1

Class: LIG_APCC_ABBA_1

Location: 1379:1384

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.655

ASA_SCORE: 86.85

COIL: 0.8152

CONS_SCORE: 0.5291

DSS_SCORE: 0.4206

HELIX: 0.0388

FCONS_SCORE: 0.9463

RIG_SCORE: 0.7059

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1380Y	TCGA-A5-A0G2	UCEC	TCGA	VSPHRD	LIG_APCC_ABBA_1	0.6009
p.S1380Y	DO41235	UCEC	ICGC	VSPHRD	LIG_APCC_ABBA_1	0.6009
p.G1385C	TCGA-CC-A9FW	LIHC	TCGA	VSPHRD	LIG_APCC_ABBA_1	0.3056
p.G1385C	DO219557	LIHC	ICGC	VSPHRD	LIG_APCC_ABBA_1	0.3056
p.V1374A	TCGA-L9-A50W	LUAD	TCGA	VSPHRD	LIG_APCC_ABBA_1	0.1944
p.V1374A	DO49872	LUAD	ICGC	VSPHRD	LIG_APCC_ABBA_1	0.1944
p.S1386F	TCGA-YG-AA3P	SKCM	TCGA	VSPHRD	LIG_APCC_ABBA_1	0.2778
p.S1386F	DO51300	SKCM	ICGC	VSPHRD	LIG_APCC_ABBA_1	0.2778
p.L1393M	DO7801	COAD	ICGC	VSPHRD	LIG_APCC_ABBA_1	0.0833
p.D1384N	DO229016	COCA	ICGC	VSPHRD	LIG_APCC_ABBA_1	0.6932
p.D1384N	DO228947	LICA	ICGC	VSPHRD	LIG_APCC_ABBA_1	0.6932
p.D1384N	DO230522	LUSC	ICGC	VSPHRD	LIG_APCC_ABBA_1	0.6932
p.I1369K	DO50330	ESAD	ICGC	VSPHRD	LIG_APCC_ABBA_1	0.0556
p.T1390P	DO234233	ESAD	ICGC	VSPHRD	LIG_APCC_ABBA_1	0.1667
p.Q1375K	DO233299	NACA	ICGC	VSPHRD	LIG_APCC_ABBA_1	0.2222
p.N1392D	DO229232	THCA	ICGC	VSPHRD	LIG_APCC_ABBA_1	0.1111
p.H1373L	SIDM00929	Chondrosarcoma	GDSC	VSPHRD	LIG_APCC_ABBA_1	0.1667
p.F1394L	SIDM01588	Endometrial Carcinoma	GDSC	VSPHRD	LIG_APCC_ABBA_1	0.0556
p.D1383V	ACH-000536	Breast Cancer	CCLE	VSPHRD	LIG_APCC_ABBA_1	0.7785
p.D1383V	BT-20	breast	COSMIC	VSPHRD	LIG_APCC_ABBA_1	0.7785
p.Q1386H	ACH-000962	Ovarian Cancer	CCLE	VSPHRD	LIG_APCC_ABBA_1	0.2778
p.Q1386H	ACH-001145	Ovarian Cancer	CCLE	VSPHRD	LIG_APCC_ABBA_1	0.2778
p.Q1386H	OC-314	ovary	COSMIC	VSPHRD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23471	Receptor-type tyrosine-protein phosphatase zeta	LIG_APCC_ABBA_1	1379:1384	VSPHRD	APC,CDC20,FZR1	0.655	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons