DegronMD

Uniprot ID: P23471

Source protein: Receptor-type tyrosine-protein phosphatase zeta

Source gene: PTPRZ1

Class: DEG_SCF_FBW7_1

Location: 1311:1318

E3 ligase: FBXW7

DEGRON score: 0.9831

ASA_SCORE: 68.3375

COIL: 0.682

CONS_SCORE: 0.6304

DSS_SCORE: 0.3366

HELIX: 0.0224

FCONS_SCORE: 1.1681

RIG_SCORE: 0.7989

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1319M	TCGA-AA-3977	COAD	TCGA	VFATPVLS	DEG_SCF_FBW7_1	0.3056
p.I1319M	DO8730	COAD	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.3056
p.P1305H	TCGA-AP-A059	UCEC	TCGA	VFATPVLS	DEG_SCF_FBW7_1	0.1667
p.P1305H	DO41361	UCEC	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.1667
p.F1312L	TCGA-CC-A7IH	LIHC	TCGA	VFATPVLS	DEG_SCF_FBW7_1	0.587
p.F1312L	DO52181	LIHC	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.587
p.V1316F	TCGA-EE-A2MF	SKCM	TCGA	VFATPVLS	DEG_SCF_FBW7_1	0.5957
p.V1316F	DO51249	SKCM	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.5957
p.P1306Q	TCGA-MP-A4T7	LUAD	TCGA	VFATPVLS	DEG_SCF_FBW7_1	0.1944
p.P1306Q	DO45370	LUAD	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.1944
p.L1323V	DO224904	BRCA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.1944
p.V1316A	DO230347	COCA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.5825
p.C1321R	DO48203	ESCA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.25
p.C1321R	DO22237	LGG	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.25
p.P1322H	DO24110	LUAD	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.2222
p.AH1303AY	DO220911	MELA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0
p.H1304Y	DO220911	MELA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.1389
p.P1306S	DO222708	MELA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.1944
p.D1311N	DO30260	OV	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.6932
p.V1311L	DO35424	PACA	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.5654
p.P1325Q	DO37770	SKCM	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.1389
p.E1315D	DO51763	STAD	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.6758
p.P1327L	DO47877	STAD	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.0833
p.D1302Y	DO41572	UCEC	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.0833
p.V1316G	DO42568	UCEC	ICGC	VFATPVLS	DEG_SCF_FBW7_1	0.6421
p.P1315H	SIDM00782	Colorectal Carcinoma	GDSC	VFATPVLS	DEG_SCF_FBW7_1	0.7694
p.P1315H	ACH-000381	Colon/Colorectal Cancer	CCLE	VFATPVLS	DEG_SCF_FBW7_1	0.7694
p.P1315H	T84	large_intestine	COSMIC	VFATPVLS	DEG_SCF_FBW7_1	0.7694
p.L1317I	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	VFATPVLS	DEG_SCF_FBW7_1	0.6063
p.L1317I	ACH-000852	Lung Cancer	CCLE	VFATPVLS	DEG_SCF_FBW7_1	0.6063
p.L1317I	NCI-H1435	lung	COSMIC	VFATPVLS	DEG_SCF_FBW7_1	0.6063
p.A1313S	SIDM00056	Thyroid Gland Carcinoma	GDSC	VFATPVLS	DEG_SCF_FBW7_1	0.6477
p.A1313S	ACH-002148	Thyroid Cancer	CCLE	VFATPVLS	DEG_SCF_FBW7_1	0.6477
p.A1313S	K5	thyroid	COSMIC	VFATPVLS	DEG_SCF_FBW7_1	0.6477
p.E1306Q	ACH-001619	Gallbladder Cancer	CCLE	VFATPVLS	DEG_SCF_FBW7_1	0.1944
p.E1306Q	ACH-002185	Pancreatic Cancer	CCLE	VFATPVLS	DEG_SCF_FBW7_1	0.1944
p.E1306Q	PL18	pancreas	COSMIC	VFATPVLS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VFATPVLS

Degron related mutations and impact score

Drug responses associated with PTPRZ1 mutations

All proteins holding degron of VFATPVLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23471	Receptor-type tyrosine-protein phosphatase zeta	DEG_SCF_FBW7_1	1311:1318	VFATPVLS	FBXW7	0.9831	More...