DegronMD

Uniprot ID: P23471

Source protein: Receptor-type tyrosine-protein phosphatase zeta

Source gene: PTPRZ1

Class: DEG_SCF_FBW7_1

Location: 781:788

E3 ligase: FBXW7

DEGRON score: 0.8895

ASA_SCORE: 66.5625

COIL: 0.7866

CONS_SCORE: 0.5779

DSS_SCORE: 0.3709

HELIX: 0.1161

FCONS_SCORE: 0.9545

RIG_SCORE: 0.7402

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A787S	TCGA-AA-3956	COAD	TCGA	LNTTPAAS	DEG_SCF_FBW7_1	0.6477
p.A787S	DO9700	COAD	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	0.6477
p.T797M	TCGA-AX-A1C9	UCEC	TCGA	LNTTPAAS	DEG_SCF_FBW7_1	0.0833
p.T797M	DO43098	UCEC	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	0.0833
p.D791V	TCGA-CM-6678	COAD	TCGA	LNTTPAAS	DEG_SCF_FBW7_1	0.25
p.D791V	DO10220	COAD	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	0.25
p.I780L	TCGA-EO-A3B0	UCEC	TCGA	LNTTPAAS	DEG_SCF_FBW7_1	0.3056
p.I780L	DO219773	UCEC	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	0.3056
p.P773H	TCGA-R5-A7ZI	STAD	TCGA	LNTTPAAS	DEG_SCF_FBW7_1	0.1111
p.P773H	DO222342	STAD	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	0.1111
p.V782L	DO228986	LICA	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	0.6765
p.A796S	DO229009	LICA	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	0.1111
p.V784M	DO45253	LIRI	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	0.7208
p.L771V	DO46657	PAAD	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	0.0556
p.K775T	DO50291	SKCM	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	0.1667
p.F789C	DO38599	STAD	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	0.3056
p.L781F	DO41758	UCEC	ICGC	LNTTPAAS	DEG_SCF_FBW7_1	0.6981
p.S789I	SIDM00935	Other Solid Cancers	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.3056
p.S789I	ACH-002091	Skin Cancer	CCLE	LNTTPAAS	DEG_SCF_FBW7_1	0.3056
p.S789I	CAL-39	vulva	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	0.3056
p.V771A	SIDM00845	Burkitt's Lymphoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.0556
p.V771A	SIDM00461	Acute Myeloid Leukemia	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.0556
p.V771A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.0556
p.V771A	SIDM01519	Head and Neck Carcinoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.0556
p.V771A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	0.0556
p.V771A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	0.0556
p.I780T	SIDM00845	Burkitt's Lymphoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.3056
p.I780T	SIDM00461	Acute Myeloid Leukemia	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.3056
p.I780T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.3056
p.I780T	SIDM01519	Head and Neck Carcinoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.3056
p.I780T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	0.3056
p.P785H	SIDM00660	Colorectal Carcinoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.7694
p.P785H	ACH-000985	Colon/Colorectal Cancer	CCLE	LNTTPAAS	DEG_SCF_FBW7_1	0.7694
p.P785H	LS-411N	large_intestine	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	0.7694
p.Q779E	SIDM00631	Breast Carcinoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.2778
p.Q779E	ACH-001358	Breast Cancer	CCLE	LNTTPAAS	DEG_SCF_FBW7_1	0.2778
p.Q779E	MDA-MB-330	breast	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	0.2778
p.V771I	SIDM01088	Endometrial Carcinoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.0556
p.V771I	ACH-000965	Endometrial/Uterine Cancer	CCLE	LNTTPAAS	DEG_SCF_FBW7_1	0.0556
p.V771I	RL95-2	endometrium	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	0.0556
p.A786D	SIDM01520	Oral Cavity Carcinoma	GDSC	LNTTPAAS	DEG_SCF_FBW7_1	0.6682
p.I783T	WM35	skin	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	0.7078
p.P780S	Sarc9371	bone	COSMIC	LNTTPAAS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LNTTPAAS

Degron related mutations and impact score

Drug responses associated with PTPRZ1 mutations

All proteins holding degron of LNTTPAAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23471	Receptor-type tyrosine-protein phosphatase zeta	DEG_SCF_FBW7_1	781:788	LNTTPAAS	FBXW7	0.8895	More...