DegronMD

Uniprot ID: P23471

Source protein: Receptor-type tyrosine-protein phosphatase zeta

Source gene: PTPRZ1

Class: DEG_SCF_FBW7_1

Location: 976:982

E3 ligase: FBXW7

DEGRON score: 0.9861

ASA_SCORE: 71.3857

COIL: 0.7854

CONS_SCORE: 0.5361

DSS_SCORE: 0.4165

HELIX: 0.1036

FCONS_SCORE: 1.0176

RIG_SCORE: 0.7548

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H968Q	TCGA-05-5425	LUAD	TCGA	LITPTAS	DEG_SCF_FBW7_1	0.1111
p.H968Q	DO26270	LUAD	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.1111
p.P970T	TCGA-17-Z056	LUAD	TCGA	LITPTAS	DEG_SCF_FBW7_1	0.1667
p.S974Y	TCGA-AJ-A3EL	UCEC	TCGA	LITPTAS	DEG_SCF_FBW7_1	0.2778
p.S974Y	TCGA-AP-A056	UCEC	TCGA	LITPTAS	DEG_SCF_FBW7_1	0.2778
p.S974Y	DO41542	UCEC	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.2778
p.S974Y	DO43971	UCEC	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.2778
p.K973T	TCGA-BR-8297	STAD	TCGA	LITPTAS	DEG_SCF_FBW7_1	0.3611
p.K973T	TCGA-D7-6522	STAD	TCGA	LITPTAS	DEG_SCF_FBW7_1	0.3611
p.K973T	DO38555	STAD	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.3611
p.K973T	DO38384	STAD	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.3611
p.K973T	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	LITPTAS	DEG_SCF_FBW7_1	0.3611
p.K973T	ACH-000510	Lung Cancer	CCLE	LITPTAS	DEG_SCF_FBW7_1	0.3611
p.K973T	NCI-H1299	lung	COSMIC	LITPTAS	DEG_SCF_FBW7_1	0.3611
p.I969L	TCGA-DK-A6B2	BLCA	TCGA	LITPTAS	DEG_SCF_FBW7_1	0.1389
p.I969L	DO48543	BLCA	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.1389
p.D977Y	DO228709	EOPC	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.7325
p.E981Q	DO52083	HNSC	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.6744
p.K969I	DO20909	KIRP	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.1389
p.D977V	DO24140	LUAD	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.7785
p.Q985H	DO232224	PBCA	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.25
p.R968I	DO38855	STAD	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.1111
p.S979I	DO38507	STAD	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.7341
p.F985V	DO41488	UCEC	ICGC	LITPTAS	DEG_SCF_FBW7_1	0.25
p.L990V	SIDM00781	Colorectal Carcinoma	GDSC	LITPTAS	DEG_SCF_FBW7_1	0.1111
p.L990V	SIDM00780	Colorectal Carcinoma	GDSC	LITPTAS	DEG_SCF_FBW7_1	0.1111
p.L990V	SNU-C2B	large_intestine	COSMIC	LITPTAS	DEG_SCF_FBW7_1	0.1111
p.D977N	ACH-000912	Lung Cancer	CCLE	LITPTAS	DEG_SCF_FBW7_1	0.6932
p.D977N	ACH-000956	Prostate Cancer	CCLE	LITPTAS	DEG_SCF_FBW7_1	0.6932
p.E980V	ACH-002167	Kidney Cancer	CCLE	LITPTAS	DEG_SCF_FBW7_1	0.7693
p.E980V	NCC010	kidney	COSMIC	LITPTAS	DEG_SCF_FBW7_1	0.7693
p.Q972R	A204	soft_tissue	COSMIC	LITPTAS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LITPTAS

Degron related mutations and impact score

Drug responses associated with PTPRZ1 mutations

All proteins holding degron of LITPTAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23471	Receptor-type tyrosine-protein phosphatase zeta	DEG_SCF_FBW7_1	976:982	LITPTAS	FBXW7	0.9861	More...