DegronMD

Uniprot ID: P23471

Source protein: Receptor-type tyrosine-protein phosphatase zeta

Source gene: PTPRZ1

Class: DEG_COP1_1

Location: 1276:1286

E3 ligase: COP1

DEGRON score: 0.6492

ASA_SCORE: 52.6273

COIL: 0.4738

CONS_SCORE: 0.535

DSS_SCORE: 0.3456

HELIX: 0.0553

FCONS_SCORE: 1.0712

RIG_SCORE: 0.7211

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1284R	DO52679	MALY	ICGC	SESSHQVVPSL	DEG_COP1_1	0.8428
p.S1279F	TCGA-FR-A3YN	SKCM	TCGA	SESSHQVVPSL	DEG_COP1_1	0.7982
p.S1279F	DO38111	SKCM	ICGC	SESSHQVVPSL	DEG_COP1_1	0.7982
p.N1276H	ACH-000993	Endometrial/Uterine Cancer	CCLE	SESSHQVVPSL	DEG_COP1_1	0.7423
p.K1281T	MIA-PaCa-2	pancreas	COSMIC	SESSHQVVPSL	DEG_COP1_1	0.7306
p.L1284V	ACH-000308	Ovarian Cancer	CCLE	SESSHQVVPSL	DEG_COP1_1	0.6765
p.L1284V	EFO-21	ovary	COSMIC	SESSHQVVPSL	DEG_COP1_1	0.6765
p.H1280Q	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SESSHQVVPSL	DEG_COP1_1	0.647
p.H1280Q	H513	pleura	COSMIC	SESSHQVVPSL	DEG_COP1_1	0.647
p.K1275T	TCGA-BS-A0UF	UCEC	TCGA	SESSHQVVPSL	DEG_COP1_1	0.3056
p.K1275T	DO41488	UCEC	ICGC	SESSHQVVPSL	DEG_COP1_1	0.3056
p.E1287D	DO8184	COAD	ICGC	SESSHQVVPSL	DEG_COP1_1	0.3056
p.E1273K	DO222557	MELA	ICGC	SESSHQVVPSL	DEG_COP1_1	0.25
p.L1273F	SIDM01184	Bladder Carcinoma	GDSC	SESSHQVVPSL	DEG_COP1_1	0.25
p.L1273F	SIDM00976	Melanoma	GDSC	SESSHQVVPSL	DEG_COP1_1	0.25
p.N1289S	SIDM01608	Endometrial Carcinoma	GDSC	SESSHQVVPSL	DEG_COP1_1	0.25
p.W1268C	DO229026	LICA	ICGC	SESSHQVVPSL	DEG_COP1_1	0.2222
p.W1268C	DO229034	LICA	ICGC	SESSHQVVPSL	DEG_COP1_1	0.2222
p.L1292V	DO51740	STAD	ICGC	SESSHQVVPSL	DEG_COP1_1	0.1667
p.S1293C	DO4080	BRCA	ICGC	SESSHQVVPSL	DEG_COP1_1	0.1389
p.Y1269F	SIDM01608	Endometrial Carcinoma	GDSC	SESSHQVVPSL	DEG_COP1_1	0.1389
p.P1269Q	ACH-001021	Liver Cancer	CCLE	SESSHQVVPSL	DEG_COP1_1	0.1389
p.P1269Q	C3A	liver	COSMIC	SESSHQVVPSL	DEG_COP1_1	0.1389
p.E1267V	TCGA-DD-AACX	LIHC	TCGA	SESSHQVVPSL	DEG_COP1_1	0.0833
p.E1267V	DO52215	LIHC	ICGC	SESSHQVVPSL	DEG_COP1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23471	Receptor-type tyrosine-protein phosphatase zeta	DEG_COP1_1	1276:1286	SESSHQVVPSL	COP1	0.6492	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons