DegronMD

Uniprot ID: P23471

Source protein: Receptor-type tyrosine-protein phosphatase zeta

Source gene: PTPRZ1

Class: DEG_SPOP_SBC_1

Location: 879:883

E3 ligase: SPOP

DEGRON score: 0.7017

ASA_SCORE: 76.46

COIL: 0.681

CONS_SCORE: 0.5505

DSS_SCORE: 0.2924

HELIX: 0.0972

FCONS_SCORE: 0.966

RIG_SCORE: 0.7613

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A885V	TCGA-23-1121	OV	TCGA	VLSTT	DEG_SPOP_SBC_1	0.2778
p.A885V	TCGA-DU-7299	LGG	TCGA	VLSTT	DEG_SPOP_SBC_1	0.2778
p.A885V	DO22342	LGG	ICGC	VLSTT	DEG_SPOP_SBC_1	0.2778
p.A885V	DO28731	OV	ICGC	VLSTT	DEG_SPOP_SBC_1	0.2778
p.G893C	TCGA-6A-AB49	LUSC	TCGA	VLSTT	DEG_SPOP_SBC_1	0.0556
p.G893C	DO52020	LUSC	ICGC	VLSTT	DEG_SPOP_SBC_1	0.0556
p.S877Y	TCGA-BS-A0UV	UCEC	TCGA	VLSTT	DEG_SPOP_SBC_1	0.2778
p.S877Y	DO42793	UCEC	ICGC	VLSTT	DEG_SPOP_SBC_1	0.2778
p.H884L	DO48451	BLCA	ICGC	VLSTT	DEG_SPOP_SBC_1	0.3056
p.E891K	DO218863	SKCA	ICGC	VLSTT	DEG_SPOP_SBC_1	0.1111
p.H884R	SIDM00313	Hodgkin's Lymphoma	GDSC	VLSTT	DEG_SPOP_SBC_1	0.3056
p.S872N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VLSTT	DEG_SPOP_SBC_1	0.1389
p.S872N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VLSTT	DEG_SPOP_SBC_1	0.1389
p.A875T	ACH-000985	Colon/Colorectal Cancer	CCLE	VLSTT	DEG_SPOP_SBC_1	0.2222
p.A875T	LS-411N	large_intestine	COSMIC	VLSTT	DEG_SPOP_SBC_1	0.2222
p.R888Q	ACH-000986	Colon/Colorectal Cancer	CCLE	VLSTT	DEG_SPOP_SBC_1	0.1944
p.R888Q	HT-115	large_intestine	COSMIC	VLSTT	DEG_SPOP_SBC_1	0.1944
p.N891D	ACH-000996	Endometrial/Uterine Cancer	CCLE	VLSTT	DEG_SPOP_SBC_1	0.1111
p.K886E	LNCaP-Clone-FGC	prostate	COSMIC	VLSTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23471	Receptor-type tyrosine-protein phosphatase zeta	DEG_SPOP_SBC_1	879:883	VLSTT	SPOP	0.7017	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1294:1298	VLSTT	SPOP	0.9883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons