DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SPOP_SBC_1

Location: 1294:1298

E3 ligase: SPOP

DEGRON score: 0.9883

ASA_SCORE: 69.5

COIL: 0.7914

CONS_SCORE: 0.3695

DSS_SCORE: 0.3645

HELIX: 0.0664

FCONS_SCORE: 1.0571

RIG_SCORE: 0.8305

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1294G	TCGA-12-0822	GBM	TCGA	VLSTT	DEG_SPOP_SBC_1	0.7532
p.V1294G	DO11064	GBM	ICGC	VLSTT	DEG_SPOP_SBC_1	0.7532
p.L1295F	TCGA-DD-AAEE	LIHC	TCGA	VLSTT	DEG_SPOP_SBC_1	0.587
p.L1296F	DO52270	LIHC	ICGC	VLSTT	DEG_SPOP_SBC_1	0.6981
p.W1308L	ACH-002170	Lung Cancer	CCLE	VLSTT	DEG_SPOP_SBC_1	0.0556
p.W1308C	ACH-002170	Lung Cancer	CCLE	VLSTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23471	Receptor-type tyrosine-protein phosphatase zeta	DEG_SPOP_SBC_1	879:883	VLSTT	SPOP	0.7017	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1294:1298	VLSTT	SPOP	0.9883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons