DegronMD

Uniprot ID: O75781

Source protein: Paralemmin-1

Source gene: PALM

Class: DEG_APCC_KENBOX_2

Location: 108:112

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9987

ASA_SCORE: 94.16

COIL: 0.4992

CONS_SCORE: 0.6764

DSS_SCORE: 0.6756

HELIX: 0.487

FCONS_SCORE: 1.5897

RIG_SCORE: 0.6321

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A112V	TCGA-63-A5MM	LUSC	TCGA	AKENA	DEG_APCC_KENBOX_2	0.5825
p.A112V	DO219153	LUSC	ICGC	AKENA	DEG_APCC_KENBOX_2	0.5825
p.A112V	ACH-000994	Endometrial/Uterine Cancer	CCLE	AKENA	DEG_APCC_KENBOX_2	0.5825
p.R100H	TCGA-D1-A167	UCEC	TCGA	AKENA	DEG_APCC_KENBOX_2	0.1111
p.R100H	DO40978	UCEC	ICGC	AKENA	DEG_APCC_KENBOX_2	0.1111
p.R100H	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKENA	DEG_APCC_KENBOX_2	0.1111
p.R100H	ACH-002062	Lymphoma	CCLE	AKENA	DEG_APCC_KENBOX_2	0.1111
p.R100H	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	AKENA	DEG_APCC_KENBOX_2	0.1111
p.T107A	DO222833	COCA	ICGC	AKENA	DEG_APCC_KENBOX_2	0.3056
p.T107A	DO229010	COCA	ICGC	AKENA	DEG_APCC_KENBOX_2	0.3056
p.T107A	DO229013	COCA	ICGC	AKENA	DEG_APCC_KENBOX_2	0.3056
p.T107A	DO229016	COCA	ICGC	AKENA	DEG_APCC_KENBOX_2	0.3056
p.T107A	DO229003	COCA	ICGC	AKENA	DEG_APCC_KENBOX_2	0.3056
p.T107A	DO229005	COCA	ICGC	AKENA	DEG_APCC_KENBOX_2	0.3056
p.T107A	DO234285	ESAD	ICGC	AKENA	DEG_APCC_KENBOX_2	0.3056
p.T107A	DO229489	LAML	ICGC	AKENA	DEG_APCC_KENBOX_2	0.3056
p.T107A	DO230659	LAML	ICGC	AKENA	DEG_APCC_KENBOX_2	0.3056
p.T107A	DO228941	LICA	ICGC	AKENA	DEG_APCC_KENBOX_2	0.3056
p.T107A	DO228945	LICA	ICGC	AKENA	DEG_APCC_KENBOX_2	0.3056
p.T107A	DO231049	LUSC	ICGC	AKENA	DEG_APCC_KENBOX_2	0.3056
p.R119Q	DO229224	THCA	ICGC	AKENA	DEG_APCC_KENBOX_2	0.1389
p.R119Q	SIDM00433	T-Lymphoblastic Leukemia	GDSC	AKENA	DEG_APCC_KENBOX_2	0.1389
p.R119Q	ACH-000795	Leukemia	CCLE	AKENA	DEG_APCC_KENBOX_2	0.1389
p.R119Q	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	AKENA	DEG_APCC_KENBOX_2	0.1389
p.S103P	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	AKENA	DEG_APCC_KENBOX_2	0.1944
p.A109T	RKO	large_intestine	COSMIC	AKENA	DEG_APCC_KENBOX_2	0.7139
p.A109T	H2461	pleura	COSMIC	AKENA	DEG_APCC_KENBOX_2	0.7139
p.V115M	SK-MEL-2	skin	COSMIC	AKENA	DEG_APCC_KENBOX_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKENA

Degron related mutations and impact score

Drug responses associated with PALM mutations

All proteins holding degron of AKENA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75781	Paralemmin-1	DEG_APCC_KENBOX_2	108:112	AKENA	APC,CDC20,FZR1	0.9987	More...