DegronMD - O75781(PALM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A112V	TCGA-63-A5MM	LUSC	TCGA	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation altering degron motif	0.5825
p.A112V	DO219153	LUSC	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation altering degron motif	0.5825
p.A112V	ACH-000994	Endometrial/Uterine Cancer	CCLE	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation altering degron motif	0.5825
p.N153S	TCGA-AP-A1DO	UCEC	TCGA	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation altering degron motif	0.5958
p.N153S	DO43250	UCEC	ICGC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation altering degron motif	0.5958
p.T158A	TCGA-BR-4361	STAD	TCGA	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation altering degron motif	0.7139
p.T158A	DO38887	STAD	ICGC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation altering degron motif	0.7139
p.R100H	TCGA-D1-A167	UCEC	TCGA	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1111
p.R100H	DO40978	UCEC	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1111
p.R100H	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1111
p.R100H	ACH-002062	Lymphoma	CCLE	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1111
p.R100H	SLVL	haematopoietic and lymphoid tissue	COSMIC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1111
p.T154M	DO49285	ALL	ICGC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation altering degron motif	0.8534
p.G161D	DO48452	BLCA	ICGC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation rewiring degron network	0.25
p.T107A	DO222833	COCA	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.3056
p.T107A	DO229010	COCA	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.3056
p.T107A	DO229013	COCA	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.3056
p.T107A	DO229016	COCA	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.3056
p.T107A	DO229003	COCA	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.3056
p.T107A	DO229005	COCA	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.3056
p.T107A	DO234285	ESAD	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.3056
p.T107A	DO229489	LAML	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.3056
p.T107A	DO230659	LAML	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.3056
p.T107A	DO228941	LICA	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.3056
p.T107A	DO228945	LICA	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.3056
p.T107A	DO231049	LUSC	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.3056
p.P163L	DO229502	SKCA	ICGC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation rewiring degron network	0.1944
p.R119Q	DO229224	THCA	ICGC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1389
p.R119Q	SIDM00433	T-Lymphoblastic Leukemia	GDSC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1389
p.R119Q	ACH-000795	Leukemia	CCLE	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1389
p.R119Q	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1389
p.G144C	SIDM00120	Prostate Carcinoma	GDSC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation rewiring degron network	0.1389
p.G144C	ACH-000979	Prostate Cancer	CCLE	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation rewiring degron network	0.1389
p.G144C	DU-145	prostate	COSMIC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation rewiring degron network	0.1389
p.N153H	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation altering degron motif	0.6312
p.N153H	ACH-000481	Lung Cancer	CCLE	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation altering degron motif	0.6312
p.N153H	NCI-H2170	lung	COSMIC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation altering degron motif	0.6312
p.S162F	SIDM00153	T-Lymphoblastic Leukemia	GDSC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation blocking phosphorylation signal	0.6667
p.S162F	ACH-000964	Leukemia	CCLE	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation blocking phosphorylation signal	0.6667
p.P142L	ACH-001634	Leukemia	CCLE	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation rewiring degron network	0.0833
p.A145T	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation blocking phosphorylation signal	0.6111
p.S103P	EM-2	haematopoietic and lymphoid tissue	COSMIC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.1944
p.E168K	CFPAC-1	pancreas	COSMIC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation rewiring degron network	0.0556
p.A109T	RKO	large intestine	COSMIC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation altering degron motif	0.7139
p.A109T	H2461	pleura	COSMIC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation altering degron motif	0.7139
p.P153A	TE-11	oesophagus	COSMIC	VSNTPLRT	DEG_SCF_FBW7_1	151:158	Mutation altering degron motif	0.7503
p.V115M	SK-MEL-2	skin	COSMIC	AKENA	DEG_APCC_KENBOX_2	108:112	Mutation rewiring degron network	0.25

Kaplan plot for PALM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PALM

UniProt ID: O75781

Entrez ID: 5064

Protein name: Paralemmin-1 (Paralemmin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PALM in