DegronMD

Uniprot ID: O75781

Source protein: Paralemmin-1

Source gene: PALM

Class: DEG_SCF_FBW7_1

Location: 151:158

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 79.925

COIL: 0.8186

CONS_SCORE: 0.3681

DSS_SCORE: 0.6379

HELIX: 0.0356

FCONS_SCORE: 0.9625

RIG_SCORE: 0.7156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N153S	TCGA-AP-A1DO	UCEC	TCGA	VSNTPLRT	DEG_SCF_FBW7_1	0.5958
p.N153S	DO43250	UCEC	ICGC	VSNTPLRT	DEG_SCF_FBW7_1	0.5958
p.T158A	TCGA-BR-4361	STAD	TCGA	VSNTPLRT	DEG_SCF_FBW7_1	0.7139
p.T158A	DO38887	STAD	ICGC	VSNTPLRT	DEG_SCF_FBW7_1	0.7139
p.T154M	DO49285	ALL	ICGC	VSNTPLRT	DEG_SCF_FBW7_1	0.8534
p.G161D	DO48452	BLCA	ICGC	VSNTPLRT	DEG_SCF_FBW7_1	0.25
p.P163L	DO229502	SKCA	ICGC	VSNTPLRT	DEG_SCF_FBW7_1	0.1944
p.G144C	SIDM00120	Prostate Carcinoma	GDSC	VSNTPLRT	DEG_SCF_FBW7_1	0.1389
p.G144C	ACH-000979	Prostate Cancer	CCLE	VSNTPLRT	DEG_SCF_FBW7_1	0.1389
p.G144C	DU-145	prostate	COSMIC	VSNTPLRT	DEG_SCF_FBW7_1	0.1389
p.N153H	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	VSNTPLRT	DEG_SCF_FBW7_1	0.6312
p.N153H	ACH-000481	Lung Cancer	CCLE	VSNTPLRT	DEG_SCF_FBW7_1	0.6312
p.N153H	NCI-H2170	lung	COSMIC	VSNTPLRT	DEG_SCF_FBW7_1	0.6312
p.S162F	SIDM00153	T-Lymphoblastic Leukemia	GDSC	VSNTPLRT	DEG_SCF_FBW7_1	0.6667
p.S162F	ACH-000964	Leukemia	CCLE	VSNTPLRT	DEG_SCF_FBW7_1	0.6667
p.P142L	ACH-001634	Leukemia	CCLE	VSNTPLRT	DEG_SCF_FBW7_1	0.0833
p.A145T	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	VSNTPLRT	DEG_SCF_FBW7_1	0.6111
p.E168K	CFPAC-1	pancreas	COSMIC	VSNTPLRT	DEG_SCF_FBW7_1	0.0556
p.P153A	TE-11	oesophagus	COSMIC	VSNTPLRT	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75781	Paralemmin-1	DEG_SCF_FBW7_1	151:158	VSNTPLRT	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons