DegronMD

Uniprot ID: P19338

Source protein: Nucleolin

Source gene: NCL

Class: DEG_SCF_SKP2-CKS1_1

Location: 210:217

E3 ligase: SKP2,CSK1

DEGRON score: 0.6036

ASA_SCORE: 89.8375

COIL: 0.7021

CONS_SCORE: 0.3083

DSS_SCORE: 0.7543

HELIX: 0.2501

FCONS_SCORE: 0.968

RIG_SCORE: 0.6354

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D205E	TCGA-AA-3845	COAD	TCGA	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.1944
p.D205E	DO10020	COAD	ICGC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P215L	TCGA-AB-2807	LAML	TCGA	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P215L	DO21589	LAML	ICGC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.7582
p.K219N	TCGA-B5-A3FA	UCEC	TCGA	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K219N	DO52402	UCEC	ICGC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.2778
p.T213S	TCGA-BR-6452	STAD	TCGA	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.7116
p.T213S	DO38404	STAD	ICGC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.7116
p.D200E	DO229036	LICA	ICGC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.D204E	DO222843	MELA	ICGC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E209A	SIDM00057	Neuroblastoma	GDSC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E209A	SIDM01098	Neuroblastoma	GDSC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E209A	SIDM00760	Small Cell Lung Carcinoma	GDSC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E203K	SIDM00710	Small Cell Lung Carcinoma	GDSC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.1389
p.E203K	ACH-000394	Lung Cancer	CCLE	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.1389
p.E207K	SIDM01048	Plasma Cell Myeloma	GDSC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.25
p.E207K	ACH-000821	Myeloma	CCLE	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.25
p.E207K	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.25
p.D204A	ACH-001664	Gastric Cancer	CCLE	AMETTPAK	DEG_SCF_SKP2-CKS1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19338	Nucleolin	DEG_SCF_SKP2-CKS1_1	210:217	AMETTPAK	SKP2,CSK1	0.6036	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons