DegronMD - P19338(NCL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E32K	TCGA-A8-A0A7	BRCA	TCGA	DDSSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.1389
p.E32K	DO5936	BRCA	ICGC	DDSSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.1389
p.D205E	TCGA-AA-3845	COAD	TCGA	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.1944
p.D205E	DO10020	COAD	ICGC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.1944
p.P215L	TCGA-AB-2807	LAML	TCGA	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation altering degron motif	0.7582
p.P215L	DO21589	LAML	ICGC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation altering degron motif	0.7582
p.K219N	TCGA-B5-A3FA	UCEC	TCGA	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.2778
p.K219N	DO52402	UCEC	ICGC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.2778
p.T213S	TCGA-BR-6452	STAD	TCGA	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation altering degron motif	0.7116
p.T213S	DO38404	STAD	ICGC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation altering degron motif	0.7116
p.V47I	TCGA-EE-A3AF	SKCM	TCGA	DDSSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.25
p.V47I	DO37911	SKCM	ICGC	DDSSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.25
p.D40N	TCGA-IG-A4P3	ESCA	TCGA	DDSSGE	DEG_Kelch_Keap1_1	39:44	Mutation altering degron motif	0.5821
p.D200E	DO229036	LICA	ICGC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.0556
p.D204E	DO222843	MELA	ICGC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.1667
p.E209A	SIDM00057	Neuroblastoma	GDSC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.3056
p.E209A	SIDM01098	Neuroblastoma	GDSC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.3056
p.E209A	SIDM00760	Small Cell Lung Carcinoma	GDSC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.3056
p.E203K	SIDM00710	Small Cell Lung Carcinoma	GDSC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.1389
p.E203K	ACH-000394	Lung Cancer	CCLE	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.1389
p.E207K	SIDM01048	Plasma Cell Myeloma	GDSC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.25
p.E207K	ACH-000821	Myeloma	CCLE	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.25
p.E207K	EJM	haematopoietic and lymphoid tissue	COSMIC	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.25
p.E38D	SIDM01753	Gastric Carcinoma	GDSC	DDSSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.3056
p.E38D	SIDM01443	Gastric Carcinoma	GDSC	DDSSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.3056
p.D204A	ACH-001664	Gastric Cancer	CCLE	AMETTPAK	DEG_SCF_SKP2-CKS1_1	210:217	Mutation rewiring degron network	0.1667

Kaplan plot for NCL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCL

UniProt ID: P19338

Entrez ID: 4691

Protein name: Nucleolin (Protein C23)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCL in