DegronMD

Uniprot ID: P19338

Source protein: Nucleolin

Source gene: NCL

Class: DEG_Kelch_Keap1_1

Location: 39:44

E3 ligase: KEAP1

DEGRON score: 0.5922

ASA_SCORE: 91.8667

COIL: 0.8882

CONS_SCORE: 0.268

DSS_SCORE: 0.7755

HELIX: 0.092

FCONS_SCORE: 0.8601

RIG_SCORE: 0.6036

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E32K	TCGA-A8-A0A7	BRCA	TCGA	DDSSGE	DEG_Kelch_Keap1_1	0.1389
p.E32K	DO5936	BRCA	ICGC	DDSSGE	DEG_Kelch_Keap1_1	0.1389
p.V47I	TCGA-EE-A3AF	SKCM	TCGA	DDSSGE	DEG_Kelch_Keap1_1	0.25
p.V47I	DO37911	SKCM	ICGC	DDSSGE	DEG_Kelch_Keap1_1	0.25
p.D40N	TCGA-IG-A4P3	ESCA	TCGA	DDSSGE	DEG_Kelch_Keap1_1	0.5821
p.E38D	SIDM01753	Gastric Carcinoma	GDSC	DDSSGE	DEG_Kelch_Keap1_1	0.3056
p.E38D	SIDM01443	Gastric Carcinoma	GDSC	DDSSGE	DEG_Kelch_Keap1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19338	Nucleolin	DEG_Kelch_Keap1_1	39:44	DDSSGE	KEAP1	0.5922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons