DegronMD

Uniprot ID: Q9UQN3

Source protein: Charged multivesicular body protein 2b

Source gene: CHMP2B

Class: DEG_SPOP_SBC_1

Location: 101:105

E3 ligase: SPOP

DEGRON score: 0.7754

ASA_SCORE: 53.18

COIL: 0.3182

CONS_SCORE: 0.7276

DSS_SCORE: 0.5181

HELIX: 0.6594

FCONS_SCORE: 1.0994

RIG_SCORE: 0.7078

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V91L	TCGA-04-1369	OV	TCGA	AMSTT	DEG_SPOP_SBC_1	0.0556
p.V91L	DO28183	OV	ICGC	AMSTT	DEG_SPOP_SBC_1	0.0556
p.M92K	TCGA-17-Z016	LUAD	TCGA	AMSTT	DEG_SPOP_SBC_1	0.0833
p.M109I	TCGA-A5-A1OF	UCEC	TCGA	AMSTT	DEG_SPOP_SBC_1	0.2222
p.A99V	TCGA-AA-A022	COAD	TCGA	AMSTT	DEG_SPOP_SBC_1	0.2778
p.A99V	DO10647	COAD	ICGC	AMSTT	DEG_SPOP_SBC_1	0.2778
p.A99V	DO233293	NACA	ICGC	AMSTT	DEG_SPOP_SBC_1	0.2778
p.A99T	TCGA-BR-8487	STAD	TCGA	AMSTT	DEG_SPOP_SBC_1	0.2778
p.A99T	DO47867	STAD	ICGC	AMSTT	DEG_SPOP_SBC_1	0.2778
p.N93S	TCGA-RQ-AAAT	DLBC	TCGA	AMSTT	DEG_SPOP_SBC_1	0.1111
p.N93S	DO219924	DLBC	ICGC	AMSTT	DEG_SPOP_SBC_1	0.1111
p.M98V	DO225086	BRCA	ICGC	AMSTT	DEG_SPOP_SBC_1	0.25
p.M98V	SIDM00497	Colorectal Carcinoma	GDSC	AMSTT	DEG_SPOP_SBC_1	0.25
p.Q93H	DO7783	COAD	ICGC	AMSTT	DEG_SPOP_SBC_1	0.1111
p.N97S	DO222620	ESCA	ICGC	AMSTT	DEG_SPOP_SBC_1	0.3333
p.D114E	DO44440	HNSC	ICGC	AMSTT	DEG_SPOP_SBC_1	0.1944
p.M98I	DO229038	LICA	ICGC	AMSTT	DEG_SPOP_SBC_1	0.25
p.M102I	DO229037	LICA	ICGC	AMSTT	DEG_SPOP_SBC_1	0.6507
p.M92I	DO229041	LICA	ICGC	AMSTT	DEG_SPOP_SBC_1	0.0833
p.M111I	DO26427	LUSC	ICGC	AMSTT	DEG_SPOP_SBC_1	0.1667
p.G100R	DO50685	ORCA	ICGC	AMSTT	DEG_SPOP_SBC_1	0.3056
p.D107G	ACH-000026	Bladder Cancer	CCLE	AMSTT	DEG_SPOP_SBC_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQN3	Charged multivesicular body protein 2b	DEG_SPOP_SBC_1	101:105	AMSTT	SPOP	0.7754	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons