DegronMD - Q9UQN3(CHMP2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V91L	TCGA-04-1369	OV	TCGA	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.0556
p.V91L	DO28183	OV	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.0556
p.M92K	TCGA-17-Z016	LUAD	TCGA	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.0833
p.M109I	TCGA-A5-A1OF	UCEC	TCGA	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.2222
p.Q123H	TCGA-AA-3510	COAD	TCGA	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.1667
p.A99V	TCGA-AA-A022	COAD	TCGA	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.2778
p.A99V	DO10647	COAD	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.2778
p.A99V	DO233293	NACA	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.2778
p.A99T	TCGA-BR-8487	STAD	TCGA	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.2778
p.A99T	DO47867	STAD	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.2778
p.N93S	TCGA-RQ-AAAT	DLBC	TCGA	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.1111
p.N93S	DO219924	DLBC	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.1111
p.M98V	DO225086	BRCA	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.25
p.M98V	SIDM00497	Colorectal Carcinoma	GDSC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.25
p.Q93H	DO7783	COAD	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.1111
p.N97S	DO222620	ESCA	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation substituting flanking lysine	0.3333
p.G122S	DO233634	GACA	ICGC	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.1389
p.D114E	DO44440	HNSC	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation substituting flanking lysine	0.1944
p.G122D	DO19248	KIRC	ICGC	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.1389
p.G122C	DO228974	LICA	ICGC	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.1389
p.M98I	DO229038	LICA	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.25
p.M102I	DO229037	LICA	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation altering degron motif	0.6507
p.M92I	DO229041	LICA	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.0833
p.E139K	DO25985	LUAD	ICGC	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.1667
p.M111I	DO26427	LUSC	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.1667
p.G100R	DO50685	ORCA	ICGC	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.3056
p.L137I	DO41020	UCEC	ICGC	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.2222
p.I132T	DO41361	UCEC	ICGC	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation altering degron motif	0.7078
p.I140S	DO41361	UCEC	ICGC	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.1389
p.D107G	ACH-000026	Bladder Cancer	CCLE	AMSTT	DEG_SPOP_SBC_1	101:105	Mutation blocking ubiquitination signal	0.7222
p.D127N	ACH-000382	Lung Cancer	CCLE	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.2778
p.E132K	ACH-000408	Esophageal Cancer	CCLE	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation altering degron motif	0.7022
p.E132K	TE-5	oesophagus	COSMIC	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation altering degron motif	0.7022
p.A138T	ACH-000553	Lung Cancer	CCLE	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.1944
p.K139N	ACH-000921	Lung Cancer	CCLE	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.1667
p.E143K	TE-5	oesophagus	COSMIC	QKENM	DEG_APCC_KENBOX_2	129:133	Mutation rewiring degron network	0.0556

Kaplan plot for CHMP2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHMP2B

UniProt ID: Q9UQN3

Entrez ID: 25978

Protein name: Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHMP2B in