DegronMD

Uniprot ID: Q9UQN3

Source protein: Charged multivesicular body protein 2b

Source gene: CHMP2B

Class: DEG_APCC_KENBOX_2

Location: 129:133

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6024

ASA_SCORE: 97

COIL: 0.1532

CONS_SCORE: 0.6601

DSS_SCORE: 0.5904

HELIX: 0.8446

FCONS_SCORE: 0.9923

RIG_SCORE: 0.7652

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q123H	TCGA-AA-3510	COAD	TCGA	QKENM	DEG_APCC_KENBOX_2	0.1667
p.G122S	DO233634	GACA	ICGC	QKENM	DEG_APCC_KENBOX_2	0.1389
p.G122D	DO19248	KIRC	ICGC	QKENM	DEG_APCC_KENBOX_2	0.1389
p.G122C	DO228974	LICA	ICGC	QKENM	DEG_APCC_KENBOX_2	0.1389
p.E139K	DO25985	LUAD	ICGC	QKENM	DEG_APCC_KENBOX_2	0.1667
p.L137I	DO41020	UCEC	ICGC	QKENM	DEG_APCC_KENBOX_2	0.2222
p.I132T	DO41361	UCEC	ICGC	QKENM	DEG_APCC_KENBOX_2	0.7078
p.I140S	DO41361	UCEC	ICGC	QKENM	DEG_APCC_KENBOX_2	0.1389
p.D127N	ACH-000382	Lung Cancer	CCLE	QKENM	DEG_APCC_KENBOX_2	0.2778
p.E132K	ACH-000408	Esophageal Cancer	CCLE	QKENM	DEG_APCC_KENBOX_2	0.7022
p.E132K	TE-5	oesophagus	COSMIC	QKENM	DEG_APCC_KENBOX_2	0.7022
p.A138T	ACH-000553	Lung Cancer	CCLE	QKENM	DEG_APCC_KENBOX_2	0.1944
p.K139N	ACH-000921	Lung Cancer	CCLE	QKENM	DEG_APCC_KENBOX_2	0.1667
p.E143K	TE-5	oesophagus	COSMIC	QKENM	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQN3	Charged multivesicular body protein 2b	DEG_APCC_KENBOX_2	129:133	QKENM	APC,CDC20,FZR1	0.6024	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons