DegronMD

Uniprot ID: Q13972

Source protein: Ras-specific guanine nucleotide-releasing factor 1

Source gene: RASGRF1

Class: DEG_SCF_SKP2-CKS1_1

Location: 913:920

E3 ligase: SKP2,CSK1

DEGRON score: 0.9016

ASA_SCORE: 60.275

COIL: 0.6766

CONS_SCORE: 0.421

DSS_SCORE: 0.4601

HELIX: 0.2938

FCONS_SCORE: 1.149

RIG_SCORE: 0.6385

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E921K	TCGA-A2-A0CX	BRCA	TCGA	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.3056
p.A913P	TCGA-CN-A63U	HNSC	TCGA	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.6392
p.E915D	TCGA-DA-A1IB	SKCM	TCGA	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.5647
p.A903T	TCGA-DX-A2IZ	SARC	TCGA	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.0556
p.A903T	SIDM00617	Hepatocellular Carcinoma	GDSC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.0556
p.Y923C	TCGA-FI-A2D5	UCEC	TCGA	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.25
p.Y923C	SIDM00487	Colorectal Carcinoma	GDSC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.25
p.Y923C	CCK-81	large_intestine	COSMIC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.25
p.R924Q	TCGA-VQ-A8DU	STAD	TCGA	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.2222
p.S911P	DO230343	COCA	ICGC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.2778
p.F917Y	DO37911	SKCM	ICGC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.7528
p.R908Q	DO51752	STAD	ICGC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.1944
p.Y907C	DO41331	UCEC	ICGC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.1667
p.Y907C	ACH-000963	Colon/Colorectal Cancer	CCLE	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.1667
p.Y907C	CCK-81	large_intestine	COSMIC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13972	Ras-specific guanine nucleotide-releasing factor 1	DEG_SCF_SKP2-CKS1_1	913:920	ANEGTPNK	SKP2,CSK1	0.9016	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons