DegronMD - Q13972(RASGRF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1060Q	TCGA-4Z-AA7W	BLCA	TCGA	FGQGWMKL	DEG_MDM2_SWIB_1	1063:1070	Mutation rewiring degron network	0.25
p.E921K	TCGA-A2-A0CX	BRCA	TCGA	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation rewiring degron network	0.3056
p.P1077T	TCGA-A5-A0VP	UCEC	TCGA	FGQGWMKL	DEG_MDM2_SWIB_1	1063:1070	Mutation rewiring degron network	0.1389
p.E1074K	TCGA-AC-A23H	BRCA	TCGA	FGQGWMKL	DEG_MDM2_SWIB_1	1063:1070	Mutation rewiring degron network	0.2222
p.F1062L	TCGA-B5-A1MR	UCEC	TCGA	FGQGWMKL	DEG_MDM2_SWIB_1	1063:1070	Mutation rewiring degron network	0.3056
p.A913P	TCGA-CN-A63U	HNSC	TCGA	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation altering degron motif	0.6392
p.E915D	TCGA-DA-A1IB	SKCM	TCGA	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation altering degron motif	0.5647
p.A903T	TCGA-DX-A2IZ	SARC	TCGA	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation rewiring degron network	0.0556
p.A903T	SIDM00617	Hepatocellular Carcinoma	GDSC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation rewiring degron network	0.0556
p.Y923C	TCGA-FI-A2D5	UCEC	TCGA	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation rewiring degron network	0.25
p.Y923C	SIDM00487	Colorectal Carcinoma	GDSC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation rewiring degron network	0.25
p.Y923C	CCK-81	large intestine	COSMIC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation rewiring degron network	0.25
p.R924Q	TCGA-VQ-A8DU	STAD	TCGA	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation rewiring degron network	0.2222
p.E1058K	DO2401	BRCA	ICGC	FGQGWMKL	DEG_MDM2_SWIB_1	1063:1070	Mutation rewiring degron network	0.1944
p.S911P	DO230343	COCA	ICGC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation rewiring degron network	0.2778
p.F917Y	DO37911	SKCM	ICGC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation altering degron motif	0.7528
p.R908Q	DO51752	STAD	ICGC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation rewiring degron network	0.1944
p.Y907C	DO41331	UCEC	ICGC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation rewiring degron network	0.1667
p.Y907C	ACH-000963	Colon/Colorectal Cancer	CCLE	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation rewiring degron network	0.1667
p.Y907C	CCK-81	large intestine	COSMIC	ANEGTPNK	DEG_SCF_SKP2-CKS1_1	913:920	Mutation rewiring degron network	0.1667
p.V1053I	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	FGQGWMKL	DEG_MDM2_SWIB_1	1063:1070	Mutation rewiring degron network	0.0556
p.V1053I	TE-6	oesophagus	COSMIC	FGQGWMKL	DEG_MDM2_SWIB_1	1063:1070	Mutation rewiring degron network	0.0556
p.Y1059H	SIDM01194	Hepatocellular Carcinoma	GDSC	FGQGWMKL	DEG_MDM2_SWIB_1	1063:1070	Mutation rewiring degron network	0.2222
p.Y1059H	SNU-449	liver	COSMIC	FGQGWMKL	DEG_MDM2_SWIB_1	1063:1070	Mutation rewiring degron network	0.2222
p.K1055R	SIDM00519	Mesothelioma	GDSC	FGQGWMKL	DEG_MDM2_SWIB_1	1063:1070	Mutation substituting flanking lysine	0.2222
p.K1055R	H2869	pleura	COSMIC	FGQGWMKL	DEG_MDM2_SWIB_1	1063:1070	Mutation substituting flanking lysine	0.2222

Kaplan plot for RASGRF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RASGRF1

UniProt ID: Q13972

Entrez ID: 5923

Protein name: Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RASGRF1 in