DegronMD

Uniprot ID: Q13972

Source protein: Ras-specific guanine nucleotide-releasing factor 1

Source gene: RASGRF1

Class: DEG_MDM2_SWIB_1

Location: 1063:1070

E3 ligase: MDM2

DEGRON score: 0.6142

ASA_SCORE: 69.1875

COIL: 0.778

CONS_SCORE: 0.5305

DSS_SCORE: 0.1628

HELIX: 0.1561

FCONS_SCORE: 1.2162

RIG_SCORE: 0.8433

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1060Q	TCGA-4Z-AA7W	BLCA	TCGA	FGQGWMKL	DEG_MDM2_SWIB_1	0.25
p.P1077T	TCGA-A5-A0VP	UCEC	TCGA	FGQGWMKL	DEG_MDM2_SWIB_1	0.1389
p.E1074K	TCGA-AC-A23H	BRCA	TCGA	FGQGWMKL	DEG_MDM2_SWIB_1	0.2222
p.F1062L	TCGA-B5-A1MR	UCEC	TCGA	FGQGWMKL	DEG_MDM2_SWIB_1	0.3056
p.E1058K	DO2401	BRCA	ICGC	FGQGWMKL	DEG_MDM2_SWIB_1	0.1944
p.V1053I	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	FGQGWMKL	DEG_MDM2_SWIB_1	0.0556
p.V1053I	TE-6	oesophagus	COSMIC	FGQGWMKL	DEG_MDM2_SWIB_1	0.0556
p.Y1059H	SIDM01194	Hepatocellular Carcinoma	GDSC	FGQGWMKL	DEG_MDM2_SWIB_1	0.2222
p.Y1059H	SNU-449	liver	COSMIC	FGQGWMKL	DEG_MDM2_SWIB_1	0.2222
p.K1055R	SIDM00519	Mesothelioma	GDSC	FGQGWMKL	DEG_MDM2_SWIB_1	0.2222
p.K1055R	H2869	pleura	COSMIC	FGQGWMKL	DEG_MDM2_SWIB_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13972	Ras-specific guanine nucleotide-releasing factor 1	DEG_MDM2_SWIB_1	1063:1070	FGQGWMKL	MDM2	0.6142	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons