DegronMD

Uniprot ID: Q13351

Source protein: Krueppel-like factor 1

Source gene: KLF1

Class: DEG_SIAH_1

Location: 144:152

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.997

ASA_SCORE: 77.6556

COIL: 0.919

CONS_SCORE: 0.4347

DSS_SCORE: 0.3747

HELIX: 0.0359

FCONS_SCORE: 0.9879

RIG_SCORE: 0.7215

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G150D	DO9708	COAD	ICGC	APDAFVGPA	DEG_SIAH_1	0.6087
p.A152S	DO233737	GACA	ICGC	APDAFVGPA	DEG_SIAH_1	0.6477
p.A152D	DO231997	ORCA	ICGC	APDAFVGPA	DEG_SIAH_1	0.6682
p.A152T	SIDM01245	T-Lymphoblastic Leukemia	GDSC	APDAFVGPA	DEG_SIAH_1	0.6028
p.R137L	ACH-000937	Leukemia	CCLE	APDAFVGPA	DEG_SIAH_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13351	Krueppel-like factor 1	DEG_SIAH_1	144:152	APDAFVGPA	SIAH1,SIAH2,SIAH3	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons