DegronMD - Q13351(KLF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A7T	TCGA-BR-8289	STAD	TCGA	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.0556
p.A7T	DO229051	LICA	ICGC	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.0556
p.A7T	DO38591	STAD	ICGC	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.0556
p.P19S	TCGA-FD-A3SO	BLCA	TCGA	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation altering degron motif	0.6752
p.P19S	DO569	BLCA	ICGC	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation altering degron motif	0.6752
p.R32H	TCGA-XK-AAIW	PRAD	TCGA	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.0556
p.R32H	DO51407	PRAD	ICGC	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.0556
p.G150D	DO9708	COAD	ICGC	APDAFVGPA	DEG_SIAH_1	144:152	Mutation altering degron motif	0.6087
p.D26Y	DO222884	COCA	ICGC	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2222
p.D26Y	SIDM00534	Colorectal Carcinoma	GDSC	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2222
p.D26Y	ACH-000986	Colon/Colorectal Cancer	CCLE	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2222
p.D26Y	HT-115	large intestine	COSMIC	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.2222
p.D25Y	DO222884	COCA	ICGC	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.25
p.L28P	DO233652	GACA	ICGC	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.1667
p.A152S	DO233737	GACA	ICGC	APDAFVGPA	DEG_SIAH_1	144:152	Mutation altering degron motif	0.6477
p.A152D	DO231997	ORCA	ICGC	APDAFVGPA	DEG_SIAH_1	144:152	Mutation altering degron motif	0.6682
p.R32L	DO229211	THCA	ICGC	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.0556
p.L8S	DO229229	THCA	ICGC	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.0833
p.A152T	SIDM01245	T-Lymphoblastic Leukemia	GDSC	APDAFVGPA	DEG_SIAH_1	144:152	Mutation altering degron motif	0.6028
p.R137L	ACH-000937	Leukemia	CCLE	APDAFVGPA	DEG_SIAH_1	144:152	Mutation rewiring degron network	0.1389
p.A16T	ACH-001529	Endometrial/Uterine Cancer	CCLE	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.3056
p.A16T	JAR	placenta	COSMIC	LGPFPD	LIG_APCC_ABBA_1	17:22	Mutation rewiring degron network	0.3056

Kaplan plot for KLF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLF1

UniProt ID: Q13351

Entrez ID: 10661

Protein name: Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KLF1 in