DegronMD

Uniprot ID: Q13351

Source protein: Krueppel-like factor 1

Source gene: KLF1

Class: LIG_APCC_ABBA_1

Location: 17:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9572

ASA_SCORE: 68.7833

COIL: 0.8935

CONS_SCORE: 0.38

DSS_SCORE: 0.4249

HELIX: 0.0748

FCONS_SCORE: 0.9792

RIG_SCORE: 0.7163

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A7T	TCGA-BR-8289	STAD	TCGA	LGPFPD	LIG_APCC_ABBA_1	0.0556
p.A7T	DO229051	LICA	ICGC	LGPFPD	LIG_APCC_ABBA_1	0.0556
p.A7T	DO38591	STAD	ICGC	LGPFPD	LIG_APCC_ABBA_1	0.0556
p.P19S	TCGA-FD-A3SO	BLCA	TCGA	LGPFPD	LIG_APCC_ABBA_1	0.6752
p.P19S	DO569	BLCA	ICGC	LGPFPD	LIG_APCC_ABBA_1	0.6752
p.R32H	TCGA-XK-AAIW	PRAD	TCGA	LGPFPD	LIG_APCC_ABBA_1	0.0556
p.R32H	DO51407	PRAD	ICGC	LGPFPD	LIG_APCC_ABBA_1	0.0556
p.D26Y	DO222884	COCA	ICGC	LGPFPD	LIG_APCC_ABBA_1	0.2222
p.D26Y	SIDM00534	Colorectal Carcinoma	GDSC	LGPFPD	LIG_APCC_ABBA_1	0.2222
p.D26Y	ACH-000986	Colon/Colorectal Cancer	CCLE	LGPFPD	LIG_APCC_ABBA_1	0.2222
p.D26Y	HT-115	large_intestine	COSMIC	LGPFPD	LIG_APCC_ABBA_1	0.2222
p.D25Y	DO222884	COCA	ICGC	LGPFPD	LIG_APCC_ABBA_1	0.25
p.L28P	DO233652	GACA	ICGC	LGPFPD	LIG_APCC_ABBA_1	0.1667
p.R32L	DO229211	THCA	ICGC	LGPFPD	LIG_APCC_ABBA_1	0.0556
p.L8S	DO229229	THCA	ICGC	LGPFPD	LIG_APCC_ABBA_1	0.0833
p.A16T	ACH-001529	Endometrial/Uterine Cancer	CCLE	LGPFPD	LIG_APCC_ABBA_1	0.3056
p.A16T	JAR	placenta	COSMIC	LGPFPD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13351	Krueppel-like factor 1	LIG_APCC_ABBA_1	17:22	LGPFPD	APC,CDC20,FZR1	0.9572	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons