DegronMD

Uniprot ID: Q8WWX9

Source protein: Selenoprotein M

Source gene: SELENOM

Class: DEG_SIAH_1

Location: 119:127

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.8834

ASA_SCORE: 76.4333

COIL: 0.7517

CONS_SCORE: 0.5338

DSS_SCORE: 0.3862

HELIX: 0.2204

FCONS_SCORE: 0.9362

RIG_SCORE: 0.7127

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D121N	SIDM02050	Colorectal Carcinoma	GDSC	APDAQVPPE	DEG_SIAH_1	0.5821
p.V129M	SIDM02059	Colorectal Carcinoma	GDSC	APDAQVPPE	DEG_SIAH_1	0.2778
p.V129M	SIDM00503	Gastric Carcinoma	GDSC	APDAQVPPE	DEG_SIAH_1	0.2778
p.V129M	FU97	stomach	COSMIC	APDAQVPPE	DEG_SIAH_1	0.2778
p.V124A	SIDM01307	Colorectal Carcinoma	GDSC	APDAQVPPE	DEG_SIAH_1	0.6936
p.V124A	SIDM01086	B-Lymphoblastic Leukemia	GDSC	APDAQVPPE	DEG_SIAH_1	0.6936
p.V124A	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	APDAQVPPE	DEG_SIAH_1	0.6936
p.P135S	SIDM00054	Pancreatic Carcinoma	GDSC	APDAQVPPE	DEG_SIAH_1	0.1111
p.P135S	SIDM01180	Hepatocellular Carcinoma	GDSC	APDAQVPPE	DEG_SIAH_1	0.1111
p.P135S	SIDM00018	Acute Myeloid Leukemia	GDSC	APDAQVPPE	DEG_SIAH_1	0.1111
p.P135S	SIDM00604	Oral Cavity Carcinoma	GDSC	APDAQVPPE	DEG_SIAH_1	0.1111
p.P135S	SIDM01473	Plasma Cell Myeloma	GDSC	APDAQVPPE	DEG_SIAH_1	0.1111
p.V123A	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	APDAQVPPE	DEG_SIAH_1	0.6936
p.V128M	FU97	stomach	COSMIC	APDAQVPPE	DEG_SIAH_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWX9	Selenoprotein M	DEG_SIAH_1	119:127	APDAQVPPE	SIAH1,SIAH2,SIAH3	0.8834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons