DegronMD

Uniprot ID: Q9NW68

Source protein: BSD domain-containing protein 1

Source gene: BSDC1

Class: DEG_SIAH_1

Location: 295:303

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.5775

ASA_SCORE: 96.4333

COIL: 0.7443

CONS_SCORE: 0.2463

DSS_SCORE: 0.4648

HELIX: 0.1981

FCONS_SCORE: 0.9008

RIG_SCORE: 0.7698

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P293S	TCGA-46-6025	LUSC	TCGA	APEARVLPK	DEG_SIAH_1	0.2778
p.P293S	TCGA-EB-A553	SKCM	TCGA	APEARVLPK	DEG_SIAH_1	0.2778
p.T292A	TCGA-CG-5721	STAD	TCGA	APEARVLPK	DEG_SIAH_1	0.25
p.T287P	DO48437	BLCA	ICGC	APEARVLPK	DEG_SIAH_1	0.1111
p.E311K	DO44425	HNSC	ICGC	APEARVLPK	DEG_SIAH_1	0.1111
p.A305V	DO22237	LGG	ICGC	APEARVLPK	DEG_SIAH_1	0.2778
p.H286Q	DO229037	LICA	ICGC	APEARVLPK	DEG_SIAH_1	0.0833
p.L304I	DO25669	LUAD	ICGC	APEARVLPK	DEG_SIAH_1	0.3056
p.P290L	DO26456	LUSC	ICGC	APEARVLPK	DEG_SIAH_1	0.1944
p.D303H	DO30580	OV	ICGC	APEARVLPK	DEG_SIAH_1	0.7688
p.S311L	DO40978	UCEC	ICGC	APEARVLPK	DEG_SIAH_1	0.1111
p.S311L	DO52402	UCEC	ICGC	APEARVLPK	DEG_SIAH_1	0.1111
p.E295Q	SIDM00837	Colorectal Carcinoma	GDSC	APEARVLPK	DEG_SIAH_1	0.6744
p.E295Q	SW48	large_intestine	COSMIC	APEARVLPK	DEG_SIAH_1	0.6744
p.S306C	ACH-000916	Lung Cancer	CCLE	APEARVLPK	DEG_SIAH_1	0.6944
p.S306C	NCI-H1573	lung	COSMIC	APEARVLPK	DEG_SIAH_1	0.6944
p.I296V	Sarc9371	bone	COSMIC	APEARVLPK	DEG_SIAH_1	0.7076
p.R297K	SNU-81	large_intestine	COSMIC	APEARVLPK	DEG_SIAH_1	0.7237
p.D308N	NCI-H187	lung	COSMIC	APEARVLPK	DEG_SIAH_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW68	BSD domain-containing protein 1	DEG_SIAH_1	295:303	APEARVLPK	SIAH1,SIAH2,SIAH3	0.5775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons